miRNAs in human cancer.

Détails

ID Serval
serval:BIB_D1699A8F534E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
miRNAs in human cancer.
Périodique
Methods in Molecular Biology
Auteur(s)
Zhong X., Coukos G., Zhang L.
ISSN
1940-6029 (Electronic)
ISSN-L
1064-3745
Statut éditorial
Publié
Date de publication
2012
Volume
822
Pages
295-306
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.Publication Status: ppublish
Résumé
MicroRNAs (miRNAs) are small (∼18-25 nucleotides), endogenous, noncoding RNAs that regulate gene expression in a sequence-specific manner via the degradation of target mRNAs or the inhibition of protein translation. miRNAs are predicted to target up to one-third of all human mRNAs. Each miRNA can target hundreds of transcripts and proteins directly or indirectly, and more than one miRNA can converge on a single target transcript; thus, the potential regulatory circuitry afforded by miRNAs is enormous. Increasing evidence is revealing that the expression of miRNAs is deregulated in cancer. High-throughput miRNA quantification technologies provide powerful tools to study global miRNA profiles. It has become progressively more apparent that, although the number of miRNAs (∼1,000) is much smaller than the number of protein-coding genes (∼22,000), miRNA expression signatures more accurately reflect the developmental lineage and tissue origin of human cancers. Large-scale studies in human cancer have further demonstrated that miRNA expression signatures are associated not only with specific tumor subtypes but also with clinical outcomes.
Mots-clé
Animals, Gene Expression Regulation, Neoplastic, Gene Silencing, Genetic Therapy, Humans, MicroRNAs/genetics, MicroRNAs/metabolism, Neoplasms/genetics, Neoplasms/metabolism
Pubmed
Création de la notice
14/10/2014 12:42
Dernière modification de la notice
03/03/2018 21:37
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