Article: article from journal or magazin.
Three new long-acting converting-enzyme inhibitors: relationship between plasma converting-enzyme activity and response to angiotensin I
Clinical Pharmacology and Therapeutics
Journal Article --- Old month value: May
Three new angiotensin converting-enzyme inhibitors were given orally to 20 men in single doses ranging from 1.25 to 40 mg. Two of them induced comparable marked inhibition of both the blood pressure response to exogenous angiotensin I and plasma converting-enzyme activity. Onset of action was relatively slow, but 21 to 24 hr after drug plasma converting-enzyme activity was still clearly reduced. The third was less active. There was a close correlation between blood pressure response on administration of angiotensin I and plasma converting-enzyme activity. There were no adverse effects. These new drugs are interesting because of their long duration of action. The measurement of plasma converting-enzyme activity seems useful for monitoring efficacy of converting-enzyme blockade and compliance to therapy.
Adult Aldosterone/blood Angiotensin I/*antagonists & inhibitors Angiotensin II/blood *Angiotensin-Converting Enzyme Inhibitors Angiotensins/*antagonists & inhibitors Blood Pressure/drug effects Dose-Response Relationship, Drug Humans Male Peptidyl-Dipeptidase A/blood Renin/blood
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