Enhanced renin secretion in adrenalectomized rats with glucocorticoid-induced hypertension

Details

Serval ID
serval:BIB_D0FDE67B27FC
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Enhanced renin secretion in adrenalectomized rats with glucocorticoid-induced hypertension
Journal
Clinical and Experimental Hypertension. Part A, Theory and Practice
Author(s)
Kasser  A., Waeber  B., Nussberger  J., Burris  J., Brunner  H. R.
ISSN
1064-1963
0730-0077 (Print)
Publication state
Published
Issued date
1985
Volume
7
Number
11
Pages
1619-28
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Abstract
The role of circulating epinephrine in the regulation of renin release was studied in unanesthetized rats with glucocorticoid-induced hypertension. Biadrenalectomized Wistar rats were made hypertensive with methylprednisolone (20 mg/kg s.c. weekly) for 2 weeks and supplemented with deoxycorticosterone pivalate (10 mg/kg s.c. weekly). Sham-operated controls received the same treatment. Baseline weight, mean intra-arterial blood pressure and heart rate of the groups were the same. In both adrenalectomized and sham-operated rats plasma renin activity was determined after a 30 min infusion of the beta-adrenoceptor stimulant isoproterenol (40 ng/min) or its vehicle. Isoproterenol had no blood pressure effect and accelerated heart rate to a similar extent in rats with and without adrenals. Plasma renin activity was significantly higher in epinephrine-deficient than in sham-operated rats. Renin secretion was significantly enhanced by isoproterenol in both groups of rats. These data therefore indicate that in rats with glucocorticoid-induced hypertension the renin-angiotensin system is activated by adrenalectomy, despite the fact that adrenal insufficiency cannot develop. It also appears that rats lacking of circulating epinephrine for a prolonged period do not exhibit an abnormal responsiveness of renin secretion to the stimulation of renal beta-adrenoceptors.
Keywords
Adrenalectomy Animals Blood Pressure/drug effects Heart Rate/drug effects Hypertension/chemically induced/*physiopathology Isoproterenol/pharmacology Male Methylprednisolone Rats Rats, Inbred Strains Renin/*secretion
Pubmed
Web of science
Create date
05/03/2008 16:39
Last modification date
20/08/2019 15:51
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