Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Role of vascular leukocytes in ovarian cancer neovascularization.
Advances in Experimental Medicine and Biology
Publication types: Journal Article ; ReviewPublication Status: ppublish
Vascular leukocytes are a unique population of CD45+ VE-cadherin+ cells with diverse functions. VLCs are capable of antigen presentation, as well as formation of endothelial-like structures in vitro and in vivo. VLCs are largely present among CD45+ cells infiltrating human ovarian carcinomas and are highly represented in the beta-defensin-VEGF-ID8 syngenic mouse model. Vascular leukocytes are a new and promising novel therapeutic target for anti-angiogenic therapy. Their unique mechanism merits thorough and extensive exploration in the future.
Animals, Antigens, CD45/biosynthesis, Female, Humans, Leukocytes/cytology, Leukocytes/physiology, Neovascularization, Pathologic, Ovarian Neoplasms/blood supply, Ovarian Neoplasms/immunology
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