Role of vascular leukocytes in ovarian cancer neovascularization.
Details
Serval ID
serval:BIB_D0F395B8F744
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Role of vascular leukocytes in ovarian cancer neovascularization.
Journal
Advances in Experimental Medicine and Biology
ISSN
0065-2598 (Print)
ISSN-L
0065-2598
Publication state
Published
Issued date
2008
Volume
622
Pages
273-280
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Vascular leukocytes are a unique population of CD45+ VE-cadherin+ cells with diverse functions. VLCs are capable of antigen presentation, as well as formation of endothelial-like structures in vitro and in vivo. VLCs are largely present among CD45+ cells infiltrating human ovarian carcinomas and are highly represented in the beta-defensin-VEGF-ID8 syngenic mouse model. Vascular leukocytes are a new and promising novel therapeutic target for anti-angiogenic therapy. Their unique mechanism merits thorough and extensive exploration in the future.
Keywords
Animals, Antigens, CD45/biosynthesis, Female, Humans, Leukocytes/cytology, Leukocytes/physiology, Neovascularization, Pathologic, Ovarian Neoplasms/blood supply, Ovarian Neoplasms/immunology
Pubmed
Web of science
Create date
14/10/2014 12:43
Last modification date
20/08/2019 16:51
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