Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing.

Détails

ID Serval
serval:BIB_D09EC71ADA0A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing.
Périodique
Gerontology
Auteur(s)
Fuellen G., Schofield P., Flatt T., Schulz R.J., Boege F., Kraft K., Rimbach G., Ibrahim S., Tietz A., Schmidt C., Köhling R., Simm A.
ISSN
1423-0003 (Electronic)
ISSN-L
0304-324X
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
62
Numéro
4
Pages
409-416
Langue
anglais
Résumé
Research into ageing and its underlying molecular basis enables us to develop and implement targeted interventions to ameliorate or cure its consequences. However, the efficacy of interventions often differs widely between individuals, suggesting that populations should be stratified or even individualized. Large-scale cohort studies in humans, similar systematic studies in model organisms as well as detailed investigations into the biology of ageing can provide individual validated biomarkers and mechanisms, leading to recommendations for targeted interventions. Human cohort studies are already ongoing, and they can be supplemented by in silico simulations. Systematic studies in animal models are made possible by the use of inbred strains or genetic reference populations of mice. Combining the two, a comprehensive picture of the various determinants of ageing and 'health span' can be studied in detail, and an appreciation of the relevance of results from model organisms to humans is emerging. The interactions between genotype and environment, particularly the psychosocial environment, are poorly studied in both humans and model organisms, presenting serious challenges to any approach to a personalized medicine of ageing. To increase the success of preventive interventions, we argue that there is a pressing need for an individualized evaluation of interventions such as physical exercise, nutrition, nutraceuticals and calorie restriction mimetics as well as psychosocial and environmental factors, separately and in combination. The expected extension of the health span enables us to refocus health care spending on individual prevention, starting in late adulthood, and on the brief period of morbidity at very old age.
Mots-clé
Health span, Healthy ageing, Cohort study, Model organism, Bioinformatics
Pubmed
Web of science
Création de la notice
26/11/2015 10:44
Dernière modification de la notice
20/08/2019 16:50
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