Article: article from journal or magazin.
Changes in D-serine levels and localization during postnatal development of the rat vestibular nuclei.
Journal of Comparative Neurology
The patterns of development of the vestibular nuclei (VN) and their main connections involving glutamate neurotransmission offer a good model for studying the function of the glial-derived neuromodulator D-serine in synaptic plasticity. In this study we show that D-serine is present in the VN and we analyzed its distribution and the levels of expression of serine racemase and D-amino acid oxidase (D-AAO) at different stages of postnatal (P) development. From birth to P21, high levels of D-serine were detected in glial cells and processes in all parts of the VN. This period corresponded to high expression of serine racemase and low expression of D-AAO. On the other hand, in the mature VN D-serine displayed very low levels and was mainly localized in neuronal cell bodies and dendrites. This drop of D-serine in adult stages corresponded to an increasing expression of D-AAO at mature stages. High levels of glial D-serine during the first 3 weeks of postnatal development correspond to an intense period of plasticity and synaptogenesis and maturation of VN afferents, suggesting that D-serine could be involved in these phenomena. These results demonstrate for the first time that changes in D-serine levels and distribution occur during postnatal development in the central nervous system. The strong decrease of D-serine levels and the glial-to-neuronal switch suggests that D-serine may have distinct functional roles depending on the developmental stage of the vestibular network.
Afferent Pathways/cytology, Afferent Pathways/growth & development, Aging/physiology, Animals, Animals, Newborn, Biological Markers/metabolism, Cell Communication/physiology, Cell Differentiation/physiology, D-Amino-Acid Oxidase/metabolism, Fluorescent Antibody Technique, Nerve Tissue Proteins/metabolism, Neuroglia/metabolism, Neuronal Plasticity/physiology, Neurons/cytology, Neurons/metabolism, Racemases and Epimerases/metabolism, Rats, Rats, Sprague-Dawley, Serine/metabolism, Stereoisomerism, Synaptic Transmission/physiology, Vestibular Nuclei/cytology, Vestibular Nuclei/growth & development
Web of science
Last modification date