Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores.

Dietrich, L.G.; Thorball, C.W.; Ryom, L.; Burkhalter, F.; Hasse, B.; Thurnheer, M.C.; Weisser, M.; Schmid, P.; Bernasconi, E.; Darling, KEA; Buvelot, H.; Fellay, J.; Ledergerber, B.; Tarr, P.E.

doi:10.1093/infdis/jiaa695

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores.

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Serval ID

serval:BIB_D0776243F8D5

Type

Article: article from journal or magazin.

Collection

Publications

Institution

UNIL/CHUV

Title

Rapid Progression of Kidney Dysfunction in People Living With HIV: Use of Polygenic and Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Risk Scores.

Journal

The Journal of infectious diseases

Author(s)

Dietrich L.G., Thorball C.W., Ryom L., Burkhalter F., Hasse B., Thurnheer M.C., Weisser M., Schmid P., Bernasconi E., Darling KEA, Buvelot H., Fellay J., Ledergerber B., Tarr P.E.

Working group(s)

Swiss HIV Cohort Study

Contributor(s)

Anagnostopoulos A., Battegay M., Bernasconi E., Boni J., Braun D.L., Bucher H.C., Calmy A., Cavassini M., Ciuffi A., Dollenmaier G., Egger M., Elzi L., Fehr J., Fellay J., Furrer H., Fux C.A., Gunthard H.F., Haerry D., Hasse B., Hirsch H.H., Hoffmann M., Hosli I., Huber M., Kahlert C.R., Kaiser L., Keiser O., Klimkait T., Kouyos R.D., Kovari H., Ledergerber B., Martinetti G., de Tejada B.M., Marzolini C., Metzner K.J., Muller N., Nicca D., Paioni P., Pantaleo G., Perreau M., Rauch A., Rudin C., Scherrer A.U., Schmid P., Speck R., Stockle M., Tarr P., Trkola A., Vernazza P., Wandeler G., Weber R., Yerly S.

ISSN

1537-6613 (Electronic)

ISSN-L

0022-1899

Publication state

Published

Issued date

15/06/2021

Peer-reviewed

Oui

Volume

223

Number

Pages

2145-2153

Language

english

Notes

Publication types: Journal Article
Publication Status: ppublish

Abstract

In people with human immunodeficiency virus (PWH), it is unknown whether genetic background associates with rapid progression of kidney dysfunction (ie, estimated glomerular filtration rate [eGFR] decrease of >5mL/min/1.73m2 per year for ≥3 consecutive years).
We obtained univariable and multivariable hazard ratios (HR) for rapid progression, based on the clinical D:A:D chronic kidney disease (CKD) risk score, antiretroviral exposures, and a polygenic risk score based on 14 769 genome-wide single nucleotide polymorphisms in white Swiss HIV Cohort Study participants.
We included 225 participants with rapid progression and 3378 rapid progression-free participants. In multivariable analysis, compared to participants with low D:A:D risk, participants with high risk had rapid progression (HR = 1.82 [95% CI, 1.28-2.60]). Compared to the first (favorable) polygenic risk score quartile, participants in the second, third, and fourth (unfavorable) quartiles had rapid progression (HR = 1.39 [95% CI, 0.94-2.06], 1.52 [95% CI, 1.04-2.24], and 2.04 [95% CI, 1.41-2.94], respectively). Recent exposure to tenofovir disoproxil fumarate was associated with rapid progression (HR = 1.36 [95% CI, 1.06-1.76]).
An individual polygenic risk score is associated with rapid progression in Swiss PWH, when analyzed in the context of clinical and antiretroviral risk factors.

Keywords

HIV infection, antiretroviral therapy, clinical risk factors, genetics, rapid progression of kidney disease

OAI-PMH

oai:serval.unil.ch:BIB_D0776243F8D5

DOI

10.1093/infdis/jiaa695

Pubmed

33151293

Web of science

000692634200016

Create date

22/11/2020 11:55