Structure and mechanism of action of serpins

Details

Serval ID
serval:BIB_D05369124911
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Structure and mechanism of action of serpins
Journal
Hematology/Oncology Clinics of North America
Author(s)
Gettins  P., Patston  P. A., Schapira  M.
ISSN
0889-8588 (Print)
Publication state
Published
Issued date
12/1992
Volume
6
Number
6
Pages
1393-408
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S.
Review --- Old month value: Dec
Abstract
Serpins have a central role in regulating proteolysis in blood coagulation, fibrinolysis, and inflammation. Congenital serpin deficiencies cause specific clinical syndromes such as thrombosis with antithrombin III deficiency or emphysema with alpha 1-antitrypsin deficiency. Acquired serpin abnormalities have also been reported, for example, increased PAI-1, which is believed to represent a major risk factor for the development of thromboembolic complications. This article has reviewed the structure/function relationships of serpins and have presented ideas concerning their mechanism of action. The implications of this information for designing drugs that could interfere with serpin function has also been described, and mention has been made of the therapeutic potential of such compounds.
Keywords
Humans Molecular Structure Mutagenesis Protease Inhibitors Serine Endopeptidases/metabolism Serpins/*chemistry/deficiency/genetics/pharmacology/*physiology
Pubmed
Web of science
Create date
25/01/2008 15:27
Last modification date
20/08/2019 15:50
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