Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
The α1-adrenergic receptors: diversity of signaling networks and regulation.
Journal of Receptor and Signal Transduction Research
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
The α(1)-adrenergic receptor (AR) subtypes (α(1a), α(1b), and α(1d)) mediate several physiological effects of epinephrine and norepinephrine. Despite several studies in recombinant systems and insight from genetically modified mice, our understanding of the physiological relevance and specificity of the α(1)-AR subtypes is still limited. Constitutive activity and receptor oligomerization have emerged as potential features regulating receptor function. Another recent paradigm is that β arrestins and G protein-coupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. The aim of this review is to summarize our current knowledge on some recently identified functional paradigms and signaling networks that might help to elucidate the functional diversity of the α(1)-AR subtypes in various organs.
Animals, Animals, Genetically Modified, Arrestins/metabolism, Epinephrine/metabolism, Norepinephrine/metabolism, Protein Isoforms/genetics, Protein Isoforms/metabolism, Receptors, Adrenergic, alpha-1/genetics, Receptors, Adrenergic, alpha-1/metabolism, Signal Transduction/physiology
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