The α1-adrenergic receptors: diversity of signaling networks and regulation.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_D04C2124AC80
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
The α1-adrenergic receptors: diversity of signaling networks and regulation.
Périodique
Journal of Receptor and Signal Transduction Research
Auteur(s)
Cotecchia S.
ISSN
1532-4281 (Electronic)
ISSN-L
1079-9893
Statut éditorial
Publié
Date de publication
2010
Peer-reviewed
Oui
Volume
30
Numéro
6
Pages
410-419
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
The α(1)-adrenergic receptor (AR) subtypes (α(1a), α(1b), and α(1d)) mediate several physiological effects of epinephrine and norepinephrine. Despite several studies in recombinant systems and insight from genetically modified mice, our understanding of the physiological relevance and specificity of the α(1)-AR subtypes is still limited. Constitutive activity and receptor oligomerization have emerged as potential features regulating receptor function. Another recent paradigm is that β arrestins and G protein-coupled receptors themselves can act as scaffolds binding a variety of proteins and this can result in growing complexity of the receptor-mediated cellular effects. The aim of this review is to summarize our current knowledge on some recently identified functional paradigms and signaling networks that might help to elucidate the functional diversity of the α(1)-AR subtypes in various organs.
Mots-clé
Animals, Animals, Genetically Modified, Arrestins/metabolism, Epinephrine/metabolism, Norepinephrine/metabolism, Protein Isoforms/genetics, Protein Isoforms/metabolism, Receptors, Adrenergic, alpha-1/genetics, Receptors, Adrenergic, alpha-1/metabolism, Signal Transduction/physiology
Pubmed
Web of science
Création de la notice
11/03/2011 17:53
Dernière modification de la notice
20/08/2019 15:50
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