Epithelial sodium channel (ENaC) and the control of blood pressure.

Détails

ID Serval
serval:BIB_D03B15751DA7
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Epithelial sodium channel (ENaC) and the control of blood pressure.
Périodique
Current Opinion In Pharmacology
Auteur(s)
Rossier B.C.
ISSN
1471-4973 (Electronic)
ISSN-L
1471-4892
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
15
Numéro
3
Pages
33-46
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
The amiloride-sensitive epithelial sodium channel (ENaC) constitutes the rate-limiting step for sodium reabsorption in epithelial cells that line the distal part of the renal tubule, the distal colon, the duct of several exocrine glands, and the lung. The activity of this channel is regulated by aldosterone and hormones involved in the maintenance of sodium balance, blood volume and blood pressure. In this review, we discuss recent advances in our understanding of ENaC function and regulation relevant to the control of sodium balance and blood pressure. The identification of novel drug targets should help in the development of the next generation of diuretics and of new therapies for the treatment of hypertension.
Mots-clé
Animals, Antihypertensive Agents/pharmacology, Blood Pressure/drug effects, Blood Pressure/physiology, Epithelial Sodium Channels/physiology, Humans, Molecular Targeted Therapy
Pubmed
Web of science
Création de la notice
18/10/2016 13:33
Dernière modification de la notice
20/08/2019 15:50
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