Gait analysis following single-shot hyaluronic acid supplementation: a pilot randomized double-blinded controlled trial.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_D033ACDC2F27
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gait analysis following single-shot hyaluronic acid supplementation: a pilot randomized double-blinded controlled trial.
Périodique
Pilot and feasibility studies
Auteur(s)
Pereira L.C., Schweizer C., Moufarrij S., Krähenbühl S.M., Favre J., Gremion G., Applegate L.A., Jolles B.M.
ISSN
2055-5784 (Print)
ISSN-L
2055-5784
Statut éditorial
Publié
Date de publication
2019
Peer-reviewed
Oui
Volume
5
Pages
56
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Viscosupplementation with new-generation, polyol-containing, cross-linked hyaluronic acid (HA) gels reduces joint inflammation in patients with knee osteoarthritis. Gait analysis is a complementary outcome measure to standard patient-reported scores and physical measures for testing the effect of HA injection. This three-arm, prospective, randomized, controlled, double-blind, feasibility pilot study investigated which gait parameters are more sensitive following a single bolus injection of polyol-containing HA for knee osteoarthritis.
Twenty-two patients with Ahlbäck grade II-III knee osteoarthritis were randomly allocated into three groups: (1) HA + mannitol (n = 9), (2) HA + sorbitol (n = 5), and (3) saline placebo (n = 8). Patients were assessed by blinded observers prior to injection and at 4 weeks post-injection (4W). Outcome measures included the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Knee Society score (KSS), EuroQol in five-dimensions (EQ-5D), VAS pain, and VAS stiffness. Gait was assessed over 30 m using a portable inertial-based data logger (Physilog®).
Differences between 4W and baseline were statistically significant for the mannitol-containing viscosupplement, with a median increase of 0.076 m/s on gait speed (p = 0.039), 0.055 m on stride length (p = 0.027), and 15 points on the KSS (p = 0.047). In contrast, the HA + sorbitol and saline groups demonstrated no significant changes from baseline to 4W in any gait parameters or self-reported outcome measures (all p > 0.3). The observed increase in gait speed is approximately 13% greater than the mean difference between healthy subjects and those with knee osteoarthritis, is clinically important, and thus is a sensitive gait parameter.
This study demonstrated gait speed and stride length are the most relevant gait parameters to investigate when assessing the effect of polyol-containing HA viscosupplementation. This study supports the need for a larger, randomized, controlled, clinical trial to assess the effect of a single-bolus HA injection versus multiple injections in people with knee osteoarthritis using both gait performance and self-reported parameters of knee function.
This study was retrospectively registered at clinicaltrials.gov on August 20, 2018, and assigned #NCT03636971.
I.
Mots-clé
Gait analysis, Hyaluronic acid, Injection, Knee, Osteoarthritis, Viscosupplementation
Pubmed
Open Access
Oui
Création de la notice
13/05/2019 7:49
Dernière modification de la notice
13/09/2019 8:38
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