Does CRP Play a Causal Role in the Development of Coronary Heart Disease: Results of a Mendelian Randomisation Experiment Involving 128,935 People

Détails

ID Serval
serval:BIB_D02FB413F6AD
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Does CRP Play a Causal Role in the Development of Coronary Heart Disease: Results of a Mendelian Randomisation Experiment Involving 128,935 People
Titre de la conférence
82nd Scientific Session of the American Heart Association
Auteur(s)
Elliot Paul, Chambers John, Sehmi Joban, Clarke Robert, Erdmann Jeanette, Braund Peter, Engert James, Ashby Deborah, Tzoulaki Ionna, Peltonen Leena, Farrall Martin, Hamsten Anders, Froguel Phillipe, Waterworth Dawn, Vollenweider Peter, Waeber Gerrard, Jarvelin Marjo-Riitta, Scott James, Hall Alistair, Schunkert Heribert, Anand Sonia, Collins Rory, Samani Nilesh, Watkins Hugh, Kooner Jaspal
Adresse
Orlando, Florida, November 14-18, 2009
ISBN
0009-7322
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
120
Série
Circulation
Pages
467-468
Langue
anglais
Notes
Meeting Abstract
Résumé
Background: C-reactive protein (CRP) is associated with risk of coronary heart disease (CHD). Whether CRP is causally associated with CHD or merely a marker of underlying atherosclerosis is uncertain.
Methods: We used a Mendelian randomisation design to investigate the causal relationship of CRP with CHD. We identified three genetic variants in the CRP locus (rs7553007, rs1130864 and rs1205) which influence CRP levels. We tested the three SNPs for association with CHD amongst 28,112 CHD cases and 100,823 controls. We then compared the observed relationship between the SNPs and CHD, with that predicted from the association of SNPs with CRP levels, and of CRP levels with CHD. Results: SNPs in the CRP locus were not associated with CHD: rs7553007, OR 0.98 (95% CI, 0.94-1.01); rs1130864, OR 1.00 (95% CI, 0.86-1.15); rs1205, OR 1.03 (95% CI, 0.99-1.07); combined OR for all three SNPs, 1.00 (95% CI, 0.97-1.02), per 20% lower CRP (figure). In contrast, the predicted OR for CHD from a 20% lower CRP level is 0.94 (95% CI, 0.94- 0.95), based on meta-analysis of observational studies.
Conclusions: Though CRP variants are associated with CRP levels, and CRP levels with risk of CHD, we observed that CRP variants are not associated with CHD risk. Our Mendelian randomisation experiment strongly argues against a causal association of CRP with CHD.
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Création de la notice
24/02/2010 11:42
Dernière modification de la notice
20/08/2019 15:50
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