Enzyme annotation in UniProtKB using Rhea.

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Serval ID
serval:BIB_CFCF95D90BD3
Type
Article: article from journal or magazin.
Collection
Publications
Institution
UNIL/CHUV
Title
Enzyme annotation in UniProtKB using Rhea.
Journal
Bioinformatics
Author(s)
Morgat A., Lombardot T., Coudert E., Axelsen K., Neto T.B., Gehant S., Bansal P., Bolleman J., Gasteiger E., de Castro E., Baratin D., Pozzato M., Xenarios I., Poux S., Redaschi N., Bridge A.
Working group(s)
UniProt Consortium
ISSN
1367-4811 (Electronic)
ISSN-L
1367-4803
Publication state
Published
Issued date
01/03/2020
Peer-reviewed
Oui
Volume
36
Number
6
Pages
1896-1901
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
Publication Status: ppublish
Abstract
To provide high quality computationally tractable enzyme annotation in UniProtKB using Rhea, a comprehensive expert-curated knowledgebase of biochemical reactions which describes reaction participants using the ChEBI (Chemical Entities of Biological Interest) ontology.
We replaced existing textual descriptions of biochemical reactions in UniProtKB with their equivalents from Rhea, which is now the standard for annotation of enzymatic reactions in UniProtKB. We developed improved search and query facilities for the UniProt website, REST API and SPARQL endpoint that leverage the chemical structure data, nomenclature and classification that Rhea and ChEBI provide.
UniProtKB at https://www.uniprot.org; UniProt REST API at https://www.uniprot.org/help/api; UniProt SPARQL endpoint at https://sparql.uniprot.org/; Rhea at https://www.rhea-db.org.
Keywords
Animals, Databases, Protein, Knowledge Bases, Rheiformes
OAI-PMH
oai:serval.unil.ch:BIB_CFCF95D90BD3
DOI
10.1093/bioinformatics/btz817
Pubmed
31688925
Web of science
000538696800033
Open Access
Yes
Create date
07/11/2019 23:34
Last modification date
17/02/2024 8:13
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