An essential role for a CD36-related receptor in pheromone detection in Drosophila.

Détails

ID Serval
serval:BIB_CFB4EF68CD1A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
An essential role for a CD36-related receptor in pheromone detection in Drosophila.
Périodique
Nature
Auteur(s)
Benton R., Vannice K.S., Vosshall L.B.
ISSN
1476-4687[electronic]
Statut éditorial
Publié
Date de publication
11/2007
Peer-reviewed
Oui
Volume
450
Numéro
7167
Pages
289-293
Langue
anglais
Résumé
The CD36 family of transmembrane receptors is present across metazoans and has been implicated biochemically in lipid binding and transport. Several CD36 proteins function in the immune system as scavenger receptors for bacterial pathogens and seem to act as cofactors for Toll-like receptors by facilitating recognition of bacterially derived lipids. Here we show that a Drosophila melanogaster CD36 homologue, Sensory neuron membrane protein (SNMP), is expressed in a population of olfactory sensory neurons (OSNs) implicated in pheromone detection. SNMP is essential for the electrophysiological responses of OSNs expressing the receptor OR67d to (Z)-11-octadecenyl acetate (cis-vaccenyl acetate, cVA), a volatile male-specific fatty-acid-derived pheromone that regulates sexual and social aggregation behaviours. SNMP is also required for the activation of the moth pheromone receptor HR13 by its lipid-derived pheromone ligand (Z)-11-hexadecenal, but is dispensable for the responses of the conventional odorant receptor OR22a to its short hydrocarbon fruit ester ligands. Finally, we show that SNMP is required for responses of OR67d to cVA when ectopically expressed in OSNs not normally activated by pheromones. Because mammalian CD36 binds fatty acids, we suggest that SNMP acts in concert with odorant receptors to capture pheromone molecules on the surface of olfactory dendrites. Our work identifies an unanticipated cofactor for odorant receptors that is likely to have a widespread role in insect pheromone detection. Moreover, these results define a unifying model for CD36 function, coupling recognition of lipid-based extracellular ligands to signalling receptors in both pheromonal communication and pathogen recognition through the innate immune system.
Mots-clé
Acetates/metabolism, Animals, Antigens, CD36/chemistry, Antigens, CD36/metabolism, Cilia/metabolism, Drosophila Proteins/chemistry, Drosophila Proteins/genetics, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, Electrophysiology, Genomics, Immunity, Innate, Male, Molecular Sequence Data, Neurons, Afferent/metabolism, Oleic Acids/metabolism, Pheromones/analysis, Pheromones/metabolism, Receptors, Odorant/metabolism, Receptors, Pheromone/chemistry, Receptors, Pheromone/genetics, Sex Characteristics, Sexual Behavior, Animal, Smell/physiology, Social Behavior
Pubmed
Web of science
Création de la notice
18/03/2008 10:36
Dernière modification de la notice
20/08/2019 15:50
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