Expression of genes encoding the pre-TCR and CD3 complex during thymus development.

Détails

Ressource 1Télécharger: serval:BIB_CF61D8671CC8.P001 (3352.96 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_CF61D8671CC8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Expression of genes encoding the pre-TCR and CD3 complex during thymus development.
Périodique
International Immunology
Auteur(s)
Wilson A., MacDonald H.R.
ISSN
0953-8178 (Print)
ISSN-L
0953-8178
Statut éditorial
Publié
Date de publication
1995
Peer-reviewed
Oui
Volume
7
Numéro
10
Pages
1659-1664
Langue
anglais
Résumé
The mature TCR is composed of a clonotypic heterodimer (alpha beta or gamma delta) associated with the invariant CD3 components (gamma, delta, epsilon and zeta). There is now considerable evidence that more immature forms of the TCR-CD3 complex (consisting of either CD3 alone or CD3 associated with a heterodimer of TCR beta and pre-T alpha) can be expressed at the cell surface on early thymocytes. These pre-TCR complexes are believed to be necessary for the ordered progression of early T cell development. We have analyzed in detail the expression of both the pre-TCR and CD3 complex at various stages of adult thymus development. Our data indicate that all CD3 components are already expressed at the mRNA level by the earliest identifiable (CD4lo) thymic precursor. In contrast, genes encoding the pre-TCR complex (pre-T alpha and fully rearranged TCR beta) are first expressed at the CD44loCD25+CD4-CD8- stage. Detectable surface expression of both CD3 and TCR beta are delayed relative to expression of the corresponding genes, suggesting the existence of other (as yet unidentified) components of the pre-TCR complex.
Mots-clé
Animals, Cell Differentiation, Female, Gene Expression Regulation, Developmental, In Situ Hybridization, Mice, Mice, Inbred C57BL, Protein Precursors/biosynthesis, Protein Precursors/genetics, RNA, Messenger/biosynthesis, RNA, Messenger/genetics, Receptor-CD3 Complex, Antigen, T-Cell/biosynthesis, Receptor-CD3 Complex, Antigen, T-Cell/genetics, Receptors, Antigen, T-Cell, alpha-beta/biosynthesis, Receptors, Antigen, T-Cell, alpha-beta/genetics, T-Lymphocytes/cytology, Thymus Gland/growth & development
Pubmed
Web of science
Open Access
Oui
Création de la notice
11/02/2010 11:38
Dernière modification de la notice
01/10/2019 6:19
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