A PET-based nomogram for oropharyngeal cancers.

Détails

ID Serval
serval:BIB_CF335D446D50
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A PET-based nomogram for oropharyngeal cancers.
Périodique
European journal of cancer
Auteur(s)
Castelli J., Depeursinge A., Ndoh V., Prior J.O., Ozsahin M., Devillers A., Bouchaab H., Chajon E., de Crevoisier R., Scher N., Jegoux F., Laguerre B., De Bari B., Bourhis J.
ISSN
1879-0852 (Electronic)
ISSN-L
0959-8049
Statut éditorial
Publié
Date de publication
04/2017
Peer-reviewed
Oui
Volume
75
Pages
222-230
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
In the context of locally advanced oropharyngeal cancer (LAOC) treated with definitive radiotherapy (RT) (combined with chemotherapy or cetuximab), the aims of this study were: (1) to identify PET-FDG parameters correlated with overall survival (OS) from a first cohort of patients; then (2) to compute a prognostic score; and (3) finally to validate this scoring system in a second independent cohort of patients.
A total of 76 consecutive patients (training cohort from Rennes) treated with chemoradiotherapy or RT with cetuximab for LAOC were used to build a predictive model of locoregional control (LRC) and OS based on PET-FDG parameters. After internal calibration and validation of this model, a nomogram and a scoring system were developed and tested in a validation cohort of 46 consecutive patients treated with definitive RT for LAOC in Lausanne.
In multivariate analysis, the metabolic tumour volume (MTV) of the primary tumour and the lymph nodes were independent predictive factors for LRC and OS. Internal calibration showed a very good adjustment between the predicted OS and the observed OS at 24 months. Using the predictive score, two risk groups were identified (median OS 42 versus 14 months, p < 0.001) and confirmed in the validation cohort from Lausanne (median OS not reached versus 26 months, p=0.008).
This is the first report of a PET-based nomogram in oropharyngeal cancer. Interestingly, it appeared stronger than the classical prognostic factors and was validated in independent cohorts markedly diverging in many aspects, which suggest that the observed signal was robust.

Mots-clé
Adolescent, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols/therapeutic use, Carboplatin/administration & dosage, Cetuximab/administration & dosage, Chemoradiotherapy/methods, Cisplatin/administration & dosage, Female, Humans, Male, Middle Aged, Neoplasm Staging, Nomograms, Oropharyngeal Neoplasms/diagnostic imaging, Oropharyngeal Neoplasms/therapy, Positron Emission Tomography Computed Tomography/methods, Prognosis, Radiotherapy, Intensity-Modulated/methods, Young Adult, Nomogram, Oropharyngeal cancer, PET, Prognostic score
Pubmed
Web of science
Création de la notice
07/03/2017 19:38
Dernière modification de la notice
20/08/2019 15:49
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