Article: article from journal or magazin.
Induction of the blood-brain barrier specific HT7 and neurothelin epitopes in endothelial cells of the chick chorioallantoic vessels by a soluble factor derived from astrocytes
Brain Research. Developmental Brain Research
PT - Journal Article PT - Research Support, Non-U.S. Gov't
Some blood-brain barrier properties of microvascular endothelial cells have been shown to be inducible by astrocytes. We tested the hypothesis that this cellular interaction is mediated by a soluble factor(s). Chick chorioallantoic vessels in ovo were constantly exposed to astrocyte-conditioned medium. We found that endothelial cells exposed to astrocyte-derived factors, but not to glioma- or endothelial cell-derived factors, expressed the HT7 antigen and neurothelin, two specific markers of the blood-brain barrier phenotype. These results indicate that a soluble factor(s) secreted by astrocytes is capable to induce specific blood-brain barrier properties in endothelial cells of non-neural origin
Animals/Antigens,CD/Antigens,CD147/Antigens,Neoplasm/Antigens,Surface/Astrocytes/physiology/Avian Proteins/Blood Proteins/Blood-Brain Barrier/Chick Embryo/Endothelium,Vascular/immunology/Epitopes/Extraembryonic Membranes/blood supply/Gene Expression/Membrane Glycoproteins/metabolism/Rats/Rats,Sprague-Dawley/Research
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