Inferring the effects of demography and selection on Drosophila melanogaster populations from a chromosome-wide scan of DNA variation.

Détails

ID Serval
serval:BIB_CEDE8D451B7A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Inferring the effects of demography and selection on Drosophila melanogaster populations from a chromosome-wide scan of DNA variation.
Périodique
Molecular Biology and Evolution
Auteur(s)
Ometto L., Glinka S., De Lorenzo D., Stephan W.
ISSN
0737-4038
Statut éditorial
Publié
Date de publication
2005
Peer-reviewed
Oui
Volume
22
Numéro
10
Pages
2119-2130
Langue
anglais
Résumé
Identifying regions of the Drosophila melanogaster genome that have been recent targets of positive Darwinian selection will provide evidence for adaptations that have helped this species to colonize temperate habitats. We have begun a search for such genomic regions by analyzing multiple loci (about 250) dispersed across the X chromosome in a putatively ancestral population from East Africa and a derived European population. For both populations we found evidence for past changes in population size. We estimated that a major bottleneck associated with the colonization of Europe occurred about 3,500-16,000 years ago. We also found that while this bottleneck can account for most of the reduction in variation observed in the European sample, there is a deficit of polymorphism in some genomic regions that cannot be explained by demography alone.
Mots-clé
Africa, Animals, Base Sequence, DNA/genetics, Demography, Drosophila melanogaster/classification, Drosophila melanogaster/genetics, Europe, Evolution, Molecular, Genetic Variation, Population, Selection (Genetics), Telomere/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/11/2007 10:48
Dernière modification de la notice
20/08/2019 15:49
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