Diagnostics Accuracy of Magnetic Resonance Imaging in Detection of Atherosclerotic Plaque Characteristics in Carotid Arteries Compared to Histology: A Systematic Review.

Details

Serval ID
serval:BIB_CE78297C3542
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Diagnostics Accuracy of Magnetic Resonance Imaging in Detection of Atherosclerotic Plaque Characteristics in Carotid Arteries Compared to Histology: A Systematic Review.
Journal
Journal of magnetic resonance imaging
Author(s)
Pakizer D., Kozel J., Elmers J., Feber J., Michel P., Školoudík D., Sirimarco G.
ISSN
1522-2586 (Electronic)
ISSN-L
1053-1807
Publication state
Published
Issued date
03/2025
Peer-reviewed
Oui
Volume
61
Number
3
Pages
1067-1093
Language
english
Notes
Publication types: Systematic Review ; Journal Article ; Comparative Study ; Review
Publication Status: ppublish
Abstract
Carotid plaque composition represents one of the main risk factors of future ischemic stroke. MRI provides excellent soft tissue contrast that can distinguish plaque characteristics. Our objective was to analyze the diagnostic accuracy of MRI imaging in the detection of carotid plaque characteristics compared to histology in patients with symptomatic and asymptomatic carotid atherosclerosis through a systematic review. After prospective registration in PROSPERO (ID CRD42022329690), Medline Ovid, Embase.com, Cochrane Library, and Web of Science Core were searched without any search limitation up to May 27, 2022 to identify eligible articles. Of the 8168 studies, 53 (37 × 1.5 T MRI, 17 × 3 T MRI) evaluated MRI accuracy in the detection of 13 specific carotid plaque characteristics in 169 comparisons. MRI demonstrated high diagnostic accuracy for detection of calcification (3 T MRI: mean sensitivity 92%/mean specificity 90%; 1.5 T MRI: mean sensitivity 81%/mean specificity 91%), fibrous cap (1.5 T: 89%/87%), unstable plaque (1.5 T: 89%/87%), intraplaque hemorrhage (1.5 T: 86%/88%), and lipid-rich necrotic core (1.5 T: 89%/79%). MRI also proved to have a high level of tissue discrimination for the carotid plaque characteristics investigated, allowing potentially for a better risk assessment and follow-up of patients who may benefit from more aggressive treatments. These results emphasize the role of MRI as the first-line imaging modality for comprehensive assessment of carotid plaque morphology, particularly for unstable plaque. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.
Keywords
Humans, Plaque, Atherosclerotic/diagnostic imaging, Magnetic Resonance Imaging/methods, Carotid Arteries/diagnostic imaging, Carotid Arteries/pathology, Carotid Artery Diseases/diagnostic imaging, Carotid Artery Diseases/pathology, Sensitivity and Specificity, Reproducibility of Results, atherosclerosis, carotid plaque, carotid stenosis, diagnostic accuracy, intraplaque hemorrhage, lipid‐rich necrotic core
Pubmed
Web of science
Open Access
Yes
Create date
12/07/2024 11:55
Last modification date
15/02/2025 9:48
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