N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study.

Détails

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Etat: Public
Version: de l'auteur
Licence: CC BY 4.0
ID Serval
serval:BIB_CE73F8CD95D4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
N-Acetyl-Cysteine Supplementation Improves Functional Connectivity Within the Cingulate Cortex in Early Psychosis: A Pilot Study.
Périodique
The international journal of neuropsychopharmacology
Auteur(s)
Mullier E., Roine T., Griffa A., Xin L., Baumann P.S., Klauser P., Cleusix M., Jenni R., Alemàn-Gómez Y., Gruetter R., Conus P., Do K.Q., Hagmann P.
ISSN
1469-5111 (Electronic)
ISSN-L
1461-1457
Statut éditorial
Publié
Date de publication
01/08/2019
Peer-reviewed
Oui
Volume
22
Numéro
8
Pages
478-487
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
There is increasing evidence that redox dysregulation, which can lead to oxidative stress and eventually to impairment of oligodendrocytes and parvalbumin interneurons, may underlie brain connectivity alterations in schizophrenia. Accordingly, we previously reported that levels of brain antioxidant glutathione in the medial prefrontal cortex were positively correlated with increased functional connectivity along the cingulum bundle in healthy controls but not in early psychosis patients. In a recent randomized controlled trial, we observed that 6-month supplementation with a glutathione precursor, N-acetyl-cysteine, increased brain glutathione levels and improved symptomatic expression and processing speed.
We investigated the effect of N-acetyl-cysteine supplementation on the functional connectivity between regions of the cingulate cortex, which have been linked to positive symptoms and processing speed decline. In this pilot study, we compared structural connectivity and resting-state functional connectivity between early psychosis patients treated with 6-month N-acetyl-cysteine (n = 9) or placebo (n = 11) supplementation with sex- and age-matched healthy control subjects (n = 74).
We observed that 6-month N-acetyl-cysteine supplementation increases functional connectivity along the cingulum and more precisely between the caudal anterior part and the isthmus of the cingulate cortex. These functional changes can be partially explained by an increase of centrality of these regions in the functional brain network.
N-acetyl-cysteine supplementation has a positive effect on functional connectivity within the cingulate cortex in early psychosis patients. To our knowledge, this is the first study suggesting that increased brain glutathione levels via N-acetyl-cysteine supplementation may improve brain functional connectivity.
Mots-clé
N-acetyl-cysteine, cingulate cortex, early psychosis, functional connectivity
Pubmed
Open Access
Oui
Création de la notice
15/07/2019 15:37
Dernière modification de la notice
21/08/2019 7:10
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