Article: article from journal or magazin.
Case report (case report): feedback on an observation with a short commentary.
Acute fatal myeloencephalopathy after combined intrathecal chemotherapy in a child with acute lymphoblastic leukemia
Medical and Pediatric Oncology
We report a case of a fatal toxic encephalomyelopathy in a 12-year-old girl due to prophylactic intrathecal injection of methotrexate and cytosine arabinoside, with a characteristic progressive symptomatology leading to death after 28 days. The location and type of neuropathological changes support the hypothesis of a direct toxic effect of methotrexate and/or cytosine arabinoside on structures directly exposed to the cerebrospinal fluid.
Antineoplastic Combined Chemotherapy Protocols/administration & dosage/*adverse effects Brain Diseases/*chemically induced/pathology Child Coma/chemically induced Cytarabine/administration & dosage/adverse effects Female Humans Injections, Spinal Leukemia, Lymphocytic, Acute/*drug therapy Methotrexate/administration & dosage/adverse effects Neoplasm Recurrence, Local Paralysis/chemically induced Paraplegia/chemically induced Spinal Cord Diseases/*chemically induced/pathology
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