Experience with angiotensin II antagonists in hypertensive patients.

Details

Serval ID
serval:BIB_CE4479240949
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Experience with angiotensin II antagonists in hypertensive patients.
Journal
Clinical and experimental pharmacology & physiology. Supplement
Author(s)
Waeber B., Burnier M., Nussberger J., Brunner H.R.
ISSN
0143-9294
Publication state
Published
Issued date
1996
Volume
3
Pages
S142-6
Language
english
Notes
Publication types: Congresses ; Review - Publication Status: ppublish
Abstract
1. The availability of orally active specific angiotensin receptor antagonists (AT1 antagonists) has opened new therapeutic choices and provided probes to test the specific role of the renin-angiotensin system in the pathogenesis of cardiovascular disease. 2. The data available so far suggest that the antihypertensive efficacy of angiotensin receptor antagonists is comparable to that of angiotensin-converting enzyme (ACE) inhibitors. This provides further evidence that this latter class of drugs exerts its effect mainly through blockade of the renin-angiotensin enzymatic cascade. As expected, the association of a diuretic exerts an equally strong additive effect to the antihypertensive efficacy of both classes of drugs. 3. The most common side effect of ACE inhibitors, dry cough, does not occur with AT1 antagonists, which confirms the long-held view that this untoward effect of the ACE inhibitors is due to renin-angiotensin-independent mechanisms. 4. Long-term studies with morbidity/mortality outcome results are needed, before a definite position can be assigned to this newcomer in the orchestra of modern antihypertensive drugs. Notwithstanding, this new class of agents already represents an exciting new addition to our therapeutic armamentarium.
Keywords
Angiotensin II, Angiotensin-Converting Enzyme Inhibitors, Diuretics, Hemodynamics, Humans, Hypertension, Kidney, Randomized Controlled Trials as Topic, Renin, Renin-Angiotensin System, Treatment Outcome
Pubmed
Create date
05/03/2008 17:40
Last modification date
20/08/2019 16:48
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