Article: article from journal or magazin.
Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior.
World Journal of Surgery
Publication types: Journal ArticlePublication Status: ppublish
The goal of this study was to provide information of prognostic value for gastric endocrine tumors. A total of 205 gastric endocrine tumors have been studied: 193 well differentiated tumors [2 gastrin cell tumors, 191 enterochromaffin-like (ECL) cell tumors] and 12 poorly differentiated carcinomas. Subtyping of ECL cell tumors (carcinoids) resulted in 152 associated with chronic atrophic gastritis (CAG) (type 1); 12 associated with hypertrophic gastropathy (HG) due to Zollinger-Ellison syndrome with multiple endocrine neoplasia type I (type 2), and 27 with no specific association (type 3, sporadic). Type 1 cases occurred most often in female (108 of 152), elderly (mean 63 years) patients, with no tumor-related death at an overall mean follow-up of 53 months. The 12 type 2 cases were equally distributed between the sexes (six of each), with a mean age of 45 years; there was one tumor-related death (49 months after diagnosis) and an overall mean survival of 84 months. Type 3 cases were mostly in men (20 of 27), with a mean age of 55 years; there were seven tumor-related deaths at a mean follow-up of 28 months. Poorly differentiated neuroendocrine carcinomas were observed in elderly patients (mean 63 years, range 41-76 years) of both sexes, with nine tumor-related deaths and a mean survival of 7 months. It was concluded that correct clinicopathologic subtyping may predict the clinical behavior of gastric endocrine tumors.
Adult, Age Factors, Aged, Carcinoid Tumor/etiology, Carcinoid Tumor/pathology, Carcinoma, Neuroendocrine/etiology, Carcinoma, Neuroendocrine/pathology, Female, Follow-Up Studies, Forecasting, Gastric Mucosa/pathology, Gastrinoma/etiology, Gastrinoma/pathology, Gastritis, Atrophic/pathology, Humans, Hypertrophy, Male, Middle Aged, Multiple Endocrine Neoplasia Type 1/pathology, Prognosis, Sex Factors, Stomach Neoplasms/etiology, Stomach Neoplasms/pathology, Survival Rate, Zollinger-Ellison Syndrome/pathology
Web of science
Last modification date