Médicaments, sexe et genre [Medicines, sex and gender]
Details
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Version: author
License: All rights reserved
State: Public
Version: author
License: All rights reserved
Serval ID
serval:BIB_CE0D6EEF8D5E
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Médicaments, sexe et genre [Medicines, sex and gender]
Journal
Revue medicale suisse
ISSN
1660-9379 (Print)
ISSN-L
1660-9379
Publication state
Published
Issued date
30/06/2021
Peer-reviewed
Oui
Volume
17
Number
744-2
Pages
1262-1264
Language
french
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Abstract
Sex-related differences affecting pharmacokinetic and pharmacodynamic processes result mostly from sex dimorphisms in body composition, and liver and kidney function, in addition to hormonal regulation of enzymes, transporters and drug receptors. Gender biases have long compromised the identification of these differences in clinical trials. They also modulate prescription patterns and therapeutic benefits. Men and women would benefit from different standard dosages of some anti-infectives, anticancer agents and other treatments requiring precise dosage adjustment. This would alleviate the well-documented excess of adverse reactions affecting women. However, the variability of pharmacological responses within each sex exceeds the average male-female difference, highlighting the importance of other criteria for therapeutic individualisation.
Keywords
Antineoplastic Agents, Female, Humans, Liver, Male, Sex Characteristics, Sex Factors
Pubmed
Create date
12/07/2021 8:37
Last modification date
21/11/2022 8:26