A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_CDDC410E5B63
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease.
Périodique
Annals of Biomedical Engineering
Auteur(s)
Andriacchi T.P., Favre J., Erhart-Hledik J.C., Chu C.R.
ISSN
1573-9686 (Electronic)
ISSN-L
0090-6964
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
43
Numéro
2
Pages
376-387
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
type validé Bibliomics
Résumé
Early detection of osteoarthritis (OA) remains a critical yet unsolved multifaceted problem. To address the multifaceted nature of OA a systems model was developed to consolidate a number of observations on the biological, mechanical and structural components of OA and identify features common to the primary risk factors for OA (aging, obesity and joint trauma) that are present prior to the development of clinical OA. This analysis supports a unified view of the pathogenesis of OA such that the risk for developing OA emerges when one of the components of the disease (e.g., mechanical) becomes abnormal, and it is the interaction with the other components (e.g., biological and/or structural) that influences the ultimate convergence to cartilage breakdown and progression to clinical OA. The model, applied in a stimulus-response format, demonstrated that a mechanical stimulus at baseline can enhance the sensitivity of a biomarker to predict cartilage thinning in a 5 year follow-up in patients with knee OA. The systems approach provides new insight into the pathogenesis of the disease and offers the basis for developing multidisciplinary studies to address early detection and treatment at a stage in the disease where disease modification has the greatest potential for a successful outcome.
Pubmed
Web of science
Création de la notice
02/04/2015 19:33
Dernière modification de la notice
20/08/2019 15:48
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