Expression of small proline rich proteins in neoplastic and inflammatory skin diseases

Détails

ID Serval
serval:BIB_CDAAB1152A8D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Expression of small proline rich proteins in neoplastic and inflammatory skin diseases
Périodique
British Journal of Dermatology
Auteur(s)
De Heller-Milev  M., Huber  M., Panizzon  R., Hohl  D.
ISSN
0007-0963 (Print)
Statut éditorial
Publié
Date de publication
10/2000
Volume
143
Numéro
4
Pages
733-40
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
BACKGROUND: The formation of the cornified cell envelope (CE) during the late stages of epidermal differentiation is essential for epidermal barrier function and protects the body against environmental attack and water loss. Formation of the CE involves the replacement of the plasma membrane by cross-linkage of precursor proteins such as involucrin, small proline rich proteins (SPRR) and loricrin. In normal epidermis, SPRR1 is restricted to appendages, SPRR2 is also expressed in interfollicular areas, while SPRR3 is completely absent; the latter is most abundant in oral epithelium. This differential expression indicates an important part for SPRRs in specific barrier requirements, and reflects their importance in the biomechanical properties of the CE. OBJECTIVES: We report here on the expression of SPRR1, SPRR2 and SPRR3 in a wide range of cutaneous neoplastic and inflammatory diseases. METHODS: We used immunohistochemistry; in addition, Northern blot analysis of malignant tumours was performed. RESULTS: Increased suprabasal expression of SPRR1 and SPRR2, but no SPRR3 expression, was noted in inflammatory dermatoses with orthokeratotic and parakeratotic squamous differentiation. By contrast, differentiating epidermal tumours such as Bowen's disease, keratoacanthoma and squamous cell carcinoma expressed SPRR3. CONCLUSIONS: As SPRRs were originally cloned on the basis of their expression in ultraviolet light-irradiated keratinocytes, the expression of SPRR3 in actinic lesions is of interest, and might serve as a diagnostic tool.
Mots-clé
Blotting, Northern Cell Cycle Proteins/metabolism Dermatitis/*metabolism Humans Intermediate Filament Proteins/metabolism Keratinocytes/metabolism Membrane Proteins Neoplasm Proteins/*metabolism Peptides/*metabolism Proteins/metabolism *Saccharomyces cerevisiae Proteins Skin/metabolism Skin Neoplasms/*metabolism Tumor Markers, Biological/*metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 16:55
Dernière modification de la notice
20/08/2019 15:48
Données d'usage