The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.

Détails

ID Serval
serval:BIB_CD8C3C9FC9A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
The Advantage of FLASH Radiotherapy Confirmed in Mini-pig and Cat-cancer Patients.
Périodique
Clinical cancer research
Auteur(s)
Vozenin M.C., De Fornel P., Petersson K., Favaudon V., Jaccard M., Germond J.F., Petit B., Burki M., Ferrand G., Patin D., Bouchaab H., Ozsahin M., Bochud F., Bailat C., Devauchelle P., Bourhis J.
ISSN
1078-0432 (Print)
ISSN-L
1078-0432
Statut éditorial
Publié
Date de publication
01/01/2019
Peer-reviewed
Oui
Volume
25
Numéro
1
Pages
35-42
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Previous studies using FLASH radiotherapy (RT) in mice showed a marked increase of the differential effect between normal tissue and tumors. To stimulate clinical transfer, we evaluated whether this effect could also occur in higher mammals.
Pig skin was used to investigate a potential difference in toxicity between irradiation delivered at an ultrahigh dose rate called "FLASH-RT" and irradiation delivered at a conventional dose rate called "Conv-RT." A clinical, phase I, single-dose escalation trial (25-41 Gy) was performed in 6 cat patients with locally advanced T2/T3N0M0 squamous cell carcinoma of the nasal planum to determine the maximal tolerated dose and progression-free survival (PFS) of single-dose FLASH-RT.
Using, respectively, depilation and fibronecrosis as acute and late endpoints, a protective effect of FLASH-RT was observed (≥20% dose-equivalent difference vs. Conv-RT). Three cats experienced no acute toxicity, whereas 3 exhibited moderate/mild transient mucositis, and all cats had depilation. With a median follow-up of 13.5 months, the PFS at 16 months was 84%.
Our results confirmed the potential advantage of FLASH-RT and provide a strong rationale for further evaluating FLASH-RT in human patients.See related commentary by Harrington, p. 3.
Pubmed
Web of science
Création de la notice
25/06/2018 16:22
Dernière modification de la notice
20/08/2019 15:48
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