Particularités du variant logopénique au sein des aphasies progressives primaires [Specificities of the logopenic variant of primary progressive aphasia].

Détails

ID Serval
serval:BIB_CD43DAC87DA3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Particularités du variant logopénique au sein des aphasies progressives primaires [Specificities of the logopenic variant of primary progressive aphasia].
Périodique
Revue Neurologique
Auteur(s)
Magnin E., Teichmann M., Martinaud O., Moreaud O., Ryff I., Belliard S., Pariente J., Moulin T., Vandel P., Démonet J.F.
ISSN
0035-3787 (Print)
ISSN-L
0035-3787
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
171
Numéro
1
Pages
16-30
Langue
français
Notes
Publication types: English Abstract ; Journal Article Publication Status: ppublish
Résumé
The logopenic variant of primary progressive aphasia is a syndrome with neuropsychological and linguistic specificities, including phonological loop impairment for which diagnosis is currently mainly based on the exclusion of the two other variants, semantic and nonfluent/agrammatic primary progressive aphasia. The syndrome may be underdiagnosed due (1) to mild language difficulties during the early stages of the disease or (2) to being mistaken for mild cognitive impairment or Alzheimer's disease when the evaluation of episodic memory is based on verbal material and (3) finally, it is not uncommon that the disorders are attributed to psychiatric co-morbidities such as, for example, anxiety. Moreover, compared to other variants of primary progressive aphasia, brain abnormalities are different. The left temporoparietal junction is initially affected. Neuropathology and biomarkers (cerebrospinal fluid, molecular amyloid nuclear imaging) frequently reveal Alzheimer's disease. Consequently this variant of primary progressive aphasia does not fall under the traditional concept of frontotemporal lobar degeneration. These distinctive features highlight the utility of correct diagnosis, classification, and use of biomarkers to show the neuropathological processes underlying logopenic primary progressive aphasia. The logopenic variant of primary progressive aphasia is a specific form of Alzheimer's disease frequently presenting a rapid decline; specific linguistic therapies are needed. Further investigation of this syndrome is needed to refine screening, improve diagnostic criteria and better understand the epidemiology and the biological mechanisms involved.
Pubmed
Web of science
Création de la notice
18/04/2015 13:41
Dernière modification de la notice
20/08/2019 16:47
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