Innovative strategies for adverse karyotype acute myeloid leukemia.

Details

Serval ID
serval:BIB_CD319BE75546
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Institution
Title
Innovative strategies for adverse karyotype acute myeloid leukemia.
Journal
Current opinion in hematology
Author(s)
Blum S., Greve G., Lübbert M.
ISSN
1531-7048 (Electronic)
ISSN-L
1065-6251
Publication state
Published
Issued date
03/2017
Peer-reviewed
Oui
Volume
24
Number
2
Pages
89-98
Language
english
Notes
Publication types: Journal Article
Publication Status: ppublish
Abstract
Adverse karyotype acute myeloid leukemia is a disease particularly of older patients, but also observed in younger patients. Despite all efforts, standard chemotherapy is still generally applied in fit patients, as already for decades, and for nearly all different subtypes of acute myeloid leukemia. Lack of more specifically targeted therapy and the often older age of the patients are complicating treatment, and in the subgroup of patients achieving a complete remission, the strikingly high frequency of relapse is a characteristic of this disease. This review aims to give an overview of current treatment approaches as well as emerging therapies.
Currently, the approach of a targeted therapy specific to the genetic and/or epigenetic aberrations detected in the individual patient is still not possible, and a 'one treatment fits all' course of action is still used, with allografting as curative consolidation. However, first immunotherapeutic approaches are emerging as treatment options and first phase 1 and 2 studies are described.
Treatment of acute myeloid leukemia with adverse karyotype is still not individualized, most treatment options currently not being curative. This can change in the near future, but recent findings will have to be implemented into larger phase 3 studies before being standard of care.

Pubmed
Web of science
Create date
24/01/2017 18:31
Last modification date
20/08/2019 16:47
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