Subthalamic Nuclei (STN) Stimulation in a Parkison Patient with a Previous Unilateral External Pallidum Lesion.

Détails

ID Serval
serval:BIB_CCE7A931DA76
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Titre
Subthalamic Nuclei (STN) Stimulation in a Parkison Patient with a Previous Unilateral External Pallidum Lesion.
Titre de la conférence
XIII International Congress on Parkinson's Disease
Auteur(s)
Carota A, Vingerhoets F, Ghika J, Albanese A
Adresse
Vancouver, Canada; 24-28 July 1999
Statut éditorial
Publié
Date de publication
1999
Volume
5
Série
Parkinsonism & Related Disorders
Pages
S 99
Langue
anglais
Résumé
STN stimulation has a demonstrated effect on akinesia and rigidity and allows to significantly reduce medication. Pallidotomy is commonly targeted on the internal globus pallidus (GP) to reduce dyskinesias and parkinsonian signs. In a patient, with an unilateral lesion restricted to the right external GP, we performed STN stimulation by means of two quadripolar electrodes. Before SIN the patient bad an UPDBS motor score of 40 in off-state and 23 in on-state (42% of improvement). the Hoehn and Yahr stage was JV in offstate and BJ in on-state. The levodopa equivalent daily dosage (LEDD) was 1050. Bilateral STN implant was performed. Successful targeting of STN was confirmed by MRl. Pet-operatively and in the immediate postoperative period, the expected improvement of parkinsonian signs on the left side was not observed with high frequency stimulation of the right STN (homolateral to pallidotomy), but it was observed as expected, on the right side with stimulation of the left STN. 'Ibe patient was discharged with a combination of bilateral STN stimulation and medication (LEDD = 750). One month after the implant the patient obtained a satisfatory motor control without dyskinesias. The UPDRS motor score was 48 with stimulation off and 18 with stimulation on (63% of improvement). No evident difference in improvement was observed between tight and left side. Side effects consisted only in dysatthria related to stimulation. The present case shows that a preexisting unilateral lesion of external GP may interfere with the immediate observation of an efficacy of STN stimulation on the lesioned side. Chronic STN stimulation was nevertheless efficacious on both sides, as evaluated one month following the implant. Partially supported by grant 3/00-05-3006.97 of Swiss National Foundation for Scientific Research.
Création de la notice
11/12/2013 23:51
Dernière modification de la notice
03/03/2018 21:29
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