Article: article from journal or magazin.
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Statines et effets indésirables musculaires [Statins and muscular side-effects]
Revue Médicale Suisse
Publication types: Comparative Study ; English Abstract ; Journal Article ; Review
Statins are effective in the treatment of hypercholesterolemia for primary and secondary prevention of cardiovascular disease. While most side effects of statins are mild and transient, muscular symptoms are relatively common (5 to 10% of patients), but rarely serious (myositis, rhabdomyolysis). In cases of myopathy, the severity of symptoms and the determination of CK (creatine kinase) determine whether discontinuation of statin is necessary. Alternative strategies are also suggested. This article reviews suggestions on the management of these complaints that are a challenge in clinical practice.
Age Factors, Aged, 80 and over, Algorithms, Anticholesteremic Agents/administration & dosage, Anticholesteremic Agents/adverse effects, Azetidines/administration & dosage, Azetidines/therapeutic use, Biopsy, Cardiovascular Diseases/prevention & control, Creatine Kinase/blood, Female, Humans, Life Style, Male, Muscle, Skeletal/pathology, Muscular Diseases/blood, Muscular Diseases/chemically induced, Myositis/chemically induced, Pain/chemically induced, Primary Prevention, Randomized Controlled Trials as Topic, Retrospective Studies, Rhabdomyolysis/chemically induced, Secondary Prevention, Sex Factors, Ubiquinone/deficiency
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