Gene variations in GSTM3 are a risk factor for Alzheimer's disease.

Détails

ID Serval
serval:BIB_CCC0A041830E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Gene variations in GSTM3 are a risk factor for Alzheimer's disease.
Périodique
Neurobiology of Aging
Auteur(s)
Hong G.S., Heun R., Jessen F., Popp J., Hentschel F., Kelemen P., Schulz A., Maier W., Kölsch H.
ISSN
1558-1497 (Electronic)
ISSN-L
0197-4580
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
30
Numéro
5
Pages
691-696
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Oxidative stress is a relevant pathomechanism in Alzheimer's disease (AD) and gene variations in the glutathione S-transferase M3 gene (GSTM3), involved in the detoxification of oxygen radicals, might influence the risk of AD. We investigated the effect of three polymorphisms in GSTM3: rs1332018 (C/A); rs1799735 (del/AGG); rs7483 (G/A), on the risk of AD in 363 AD patients and 358 healthy controls. Single marker association analyses revealed that the AGG/AGG genotype of the GSTM3 rs1799735 (del/AGG) polymorphism was associated with an increased risk of AD (p=0.05), especially in the group of APOE4-allele non-carriers (p=0.004; OR=2.07). Examination of the haplotypes identified a two-marker haplotype (C/AGG) consisting of rs1332018 (C/A) and rs1799735 (del/AGG) to increase the risk of AD (p=0.029), this effect was also most prevalent in APOE4-allele non-carriers (p=0.009; OR=1.95). The population attributable risk of this haplotype in APOE4-allele non-carriers was 32.2%. Our results suggest that there is a group of AD patients in which variations in metabolism of oxidative stress play an important role.
Mots-clé
Adult, Aged, Aged, 80 and over, Alzheimer Disease/diagnosis, Alzheimer Disease/enzymology, Apolipoprotein E4/genetics, Brain/enzymology, Brain/physiopathology, DNA Mutational Analysis, Female, Gene Frequency/genetics, Genetic Markers/genetics, Genetic Predisposition to Disease/genetics, Genetic Testing, Genetic Variation/genetics, Glutathione Transferase/genetics, Haplotypes, Humans, Male, Middle Aged, Oxidative Stress/genetics, Polymorphism, Genetic/genetics, Risk Factors
Pubmed
Création de la notice
29/10/2012 11:43
Dernière modification de la notice
03/03/2018 21:29
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