Targeting endoplasmic reticulum signaling pathways in cancer.

Détails

ID Serval
serval:BIB_CC94D4E9246F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Targeting endoplasmic reticulum signaling pathways in cancer.
Périodique
Acta Oncologica
Auteur(s)
Martinon F.
ISSN
1651-226X (Electronic)
ISSN-L
0284-186X
Statut éditorial
Publié
Date de publication
2012
Volume
51
Numéro
7
Pages
822-830
Langue
anglais
Résumé
The endoplasmic reticulum (ER) orchestrates the production of membrane-bound and secreted proteins. However, its capacity to process the synthesis and folding of protein is limited. Protein overload and the accumulation of misfolded proteins in the ER trigger an adaptive response known as the ER-stress response that is mediated by specific ER-anchored signaling pathways. This response regulates cell functions aimed at restoring cellular homeostasis or at promoting apoptosis of irreparably damaged cells. Activation or deregulation of ER-signaling pathways has been associated with various diseases including cancer. Here we discuss how tumors engage ER-signaling pathways to promote tumorigenesis and how manipulation of this process by anticancer drugs may contribute to cancer treatment.
Pubmed
Web of science
Création de la notice
07/12/2012 11:39
Dernière modification de la notice
03/03/2018 21:28
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