Recombinant human growth hormone in chronic and acute respiratory insufficiency.

Details

Serval ID
serval:BIB_CC81DE2FF1B2
Type
Article: article from journal or magazin.
Publication sub-type
Review (review): journal as complete as possible of one specific subject, written based on exhaustive analyses from published work.
Collection
Publications
Title
Recombinant human growth hormone in chronic and acute respiratory insufficiency.
Journal
Hormone Research
Author(s)
Pichard C., Jolliet P., Chevrolet J.C., Romand J.A., Slosman D.
ISSN
0301-0163 (Print)
ISSN-L
0301-0163
Publication state
Published
Issued date
1996
Peer-reviewed
Oui
Volume
46
Number
4-5
Pages
222-229
Language
english
Notes
Publication types: Journal Article ; ReviewPublication Status: ppublish
Abstract
Chronic respiratory insufficiency leads to protein-calorie malnutrition (PCM). PCM results in increased morbidity (e.g., infection), which in turn promotes further body wasting. The latter leads to respiratory muscle dysfunction and acute respiratory failure. Nutritional support alone is generally insufficient to counterbalance this hypoxemic and stress-related muscle catabolism. Recombinant human growth hormone (rhGH) can preserve or replenish nitrogen reserves, mostly contained in body muscle mass. It was hypothesized that rhGH, through its ability to improve muscle mass and function, could be a valuable therapeutic adjunct in both chronic and acute respiratory insufficiency. The results are controversial, and the beneficial effects of rhGH in patients with chronic and acute respiratory insufficiency, in terms of improvement of respiratory function, morbidity, and quality of life, remain to be shown. Well-designed studies, specifically targeting these end points as well as cost-effectiveness, are needed to better define the place of rhGH in the nutritional support of these patients.
Keywords
Acute Disease, Chronic Disease, Human Growth Hormone/therapeutic use, Humans, Nutritional Support, Protein-Energy Malnutrition/etiology, Protein-Energy Malnutrition/therapy, Recombinant Proteins/therapeutic use, Respiration, Artificial, Respiratory Insufficiency/complications, Respiratory Insufficiency/drug therapy
Pubmed
Web of science
Create date
25/07/2013 14:29
Last modification date
20/08/2019 15:47
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