Dopaminergic control of aldosterone secretion in hypertensive patients chronically treated with an angiotensin converting enzyme inhibitor

Détails

ID Serval
serval:BIB_CC507B139D54
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Dopaminergic control of aldosterone secretion in hypertensive patients chronically treated with an angiotensin converting enzyme inhibitor
Périodique
Hormone and Metabolic Research
Auteur(s)
Waeber  B., Nussberger  J., Schaller  M. D., Gomez  H. J., Brunner  H. R.
ISSN
0018-5043 (Print)
Statut éditorial
Publié
Date de publication
01/1986
Volume
18
Numéro
1
Pages
60-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jan
Résumé
To investigate whether dopamine plays a role in the regulation of aldosterone secretion during long-term blockade of the renin-angiotensin system, we studied the effect of metoclopramide, a competitive antagonist of dopamine, in 6 patients with essential hypertension chronically treated with the angiotensin converting enzyme inhibitor enalapril. All but one of these patients received a diuretic in addition to enalapril. Six hours after the daily morning dose of enalapril (10-40 mg p.o.) a 10 mg bolus dose of metoclopramide was injected intravenously. In one patient a hypotensive episode developed following metoclopramide administration. In the 5 other patients plasma aldosterone significantly rose within 30 min after metoclopramide from 51 +/- 8.7 to 128.2 +/- 29.2 pg/ml. This metoclopramide-induced release of aldosterone occurred in the absence of concomitant changes in circulating angiotensin 11, potassium and ACTH levels. Metoclopramide given during chronic blockade of the renin-angiotensin system caused anxiety and agitation in 2 patients. The increase in plasma aldosterone following competitive dopamine blockade in the face of chronic angiotensin converting enzyme inhibition, unchanged plasma potassium and ACTH levels strongly suggests that in hypertensive patients, dopamine exerts a direct inhibitory effect on aldosterone secretion.
Mots-clé
Adrenocorticotropic Hormone/blood Adult Aged Aldosterone/blood/*secretion Angiotensin II/blood *Angiotensin-Converting Enzyme Inhibitors Dopamine/*physiology Dopamine Antagonists Enalapril/*therapeutic use Female Humans Hypertension/*blood/drug therapy/enzymology Male Metoclopramide/pharmacology Middle Aged Peptidyl-Dipeptidase A/blood
Pubmed
Web of science
Création de la notice
05/03/2008 17:39
Dernière modification de la notice
03/03/2018 21:28
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