Effect of curing Helicobacter pylori infection on intragastric pH during treatment with omeprazole

Détails

ID Serval
serval:BIB_CC34AF57F6CA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effect of curing Helicobacter pylori infection on intragastric pH during treatment with omeprazole
Périodique
Gut
Auteur(s)
Verdu  E. F., Armstrong  D., Idstrom  J. P., Labenz  J., Stolte  M., Dorta  G., Borsch  G., Blum  A. L.
ISSN
0017-5749 (Print)
Statut éditorial
Publié
Date de publication
12/1995
Volume
37
Numéro
6
Pages
743-8
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Dec
Résumé
It has been shown that omeprazole treatment produces higher intragastric pH values in Helicobacter pylori positive subjects than in H pylori negative subjects. This study aimed to investigate the effect of curing H pylori on the intragastric pH in both the presence and absence of omeprazole therapy. Twenty four hour intragastric pH recordings were performed before and after a one week course of omeprazole (20 mg once daily) in 18 H pylori positive subjects and were repeated after the infection had been cured. In the absence of omeprazole, the total 24 hour pH values before cure did not differ from those afterwards. During omeprazole treatment the 24 hour pH values were much higher before (median (95% CI) 5.4: 4.3, 6.0), than after cure of infection (3.6: 2.1, 4.4; p < 0.001). The omeprazole induced fall in H+ activity before cure of H pylori did not, however, differ from that afterwards. It is concluded that the apparently greater antisecretory effect of omeprazole during H pylori infection may be a result of the production of acid neutralising compounds by the H pylori. Although a direct interaction between H pylori and omeprazole cannot be excluded, it seems unlikely.
Mots-clé
Adult Anti-Ulcer Agents/*pharmacology Antibodies, Bacterial/blood Breath Tests Female Gastric Acid/*metabolism Gastric Acidity Determination Helicobacter Infections/drug therapy/*metabolism *Helicobacter pylori/immunology Humans Hydrogen-Ion Concentration/drug effects Male Omeprazole/*pharmacology
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 16:48
Dernière modification de la notice
09/05/2019 1:20
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