IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells.

Détails

Ressource 1Télécharger: 1-s2.0-S2211124719305595-main.pdf (16653.31 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY-NC-ND 4.0
ID Serval
serval:BIB_CC1A2AB80EDD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
IL-4Rα-Expressing B Cells Are Required for CXCL13 Production by Fibroblastic Reticular Cells.
Périodique
Cell Reports
Auteur(s)
Dubey L.K., Ludewig B., Luther S.A., Harris N.L.
ISSN
2211-1247 (Electronic)
Statut éditorial
Publié
Date de publication
21/05/2019
Peer-reviewed
Oui
Volume
27
Numéro
8
Pages
2442-2458.e5
Langue
anglais
Résumé
Adaptive type 2 immune responses against the intestinal helminth Heligmosomoides polygyrus (Hp) require the interaction of follicle-associated CXCR5 <sup>+</sup> dendritic cells with naive T cells in the draining mesenteric lymph nodes (mLNs). However, the source of CXCL13 responsible for attracting CXCR5 <sup>+</sup> dendritic cells has remained unclear. Using multiplex imaging combined with deep tissue analysis, we observed new CXCL13 <sup>+</sup> fibroblastic reticular cells surrounding paracortical and cortical B cell follicles in the mLNs of infected mice. CXCL13 <sup>+</sup> fibroblasts expressed markers of marginal reticular cells (MRCs), and their expansion required lymphotoxin (LT)-dependent interactions between IL-4Rα-expressing B cells and CCL19 <sup>+</sup> fibroblasts. Infection-induced follicles did not necessarily contain follicular dendritic cells (FDCs), indicating that CXCL13 <sup>+</sup> fibroblasts may instead drive their formation. These data reveal a role for lymphotoxin signaling to CCL19 <sup>+</sup> fibroblasts in the development of CXCL13 <sup>+</sup> MRC-like cells and adaptive type 2 immunity in response to helminth infection.
Mots-clé
CXCL13, Heligmosomoides polygyrus, IL-4Rα, MAdCAM-1, fibroblastic reticular cells, helminth infection, interfollicular region, intestinal infection, marginal reticular cells, mesenteric lymph node
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/05/2019 9:41
Dernière modification de la notice
20/08/2019 15:46
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