Regulation of protective immunity against Leishmania major in mice.

Détails

ID Serval
serval:BIB_CC10C6047D11
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Regulation of protective immunity against Leishmania major in mice.
Périodique
Current Opinion in Immunology
Auteur(s)
Louis J., Himmelrich H., Parra-Lopez C., Tacchini-Cottier F., Launois P.
ISSN
0952-7915 (Print)
ISSN-L
0952-7915
Statut éditorial
Publié
Date de publication
1998
Volume
10
Numéro
4
Pages
459-464
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Resolution of lesions induced by Leishmania major in mice results from the development of Th1 responses. Cytokines produced by Th1 cells activate macrophages to a parasiticidal state. The development of Th2 responses in mice from a few strains underlies susceptibility to infection. Cytokines produced by Th2 cells exacerbate the development of lesions because of their deactivating properties for macrophages. This murine model of infection has provided significant insight into the mechanisms intrinsic to the differentiation of disparate CD4+ T cell subsets in vivo in animals from different genetic backgrounds.
Mots-clé
Animals, CD4-Positive T-Lymphocytes/cytology, CD4-Positive T-Lymphocytes/immunology, Cell Differentiation, Disease Susceptibility, Immunity, Innate, Leishmania major/immunology, Leishmaniasis, Cutaneous/immunology, Leishmaniasis, Cutaneous/prevention & control, Mice
Pubmed
Web of science
Création de la notice
24/01/2008 16:09
Dernière modification de la notice
20/08/2019 16:46
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