99mTc-2-Methoxy-Isobutyl-Isonitril in der Diagnostik der koronaren Herzkrankheit: Ergebnisse einer Multizenterstudie. [99mTc-2-methoxy-isobutyl-isonitrile in the diagnosis of coronary heart disease: results of a multicenter study]

Détails

ID Serval
serval:BIB_CC0BF3D3CBA5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
99mTc-2-Methoxy-Isobutyl-Isonitril in der Diagnostik der koronaren Herzkrankheit: Ergebnisse einer Multizenterstudie. [99mTc-2-methoxy-isobutyl-isonitrile in the diagnosis of coronary heart disease: results of a multicenter study]
Périodique
Nuklearmedizin
Auteur(s)
Hoffken  H., Joseph  K., Alexander  C., Bauer  R., Berberich  R., Bischof-Delaloye  A., Bottger  I., Botsch  H., Bull  U., Delaloye  B., Eichstadt H., Eissner D., Feine U., Feistel H., Fischer M., Gebhardt U., Hahn K., Heidenreich P., Hundeshagen H., Knapp W.H., Krause T., Kropp J., Larock M.P., Leisner B., Locher J.T., Lottes G., Lowenstein O., Muller S., Mullerschauenburg W., Reiners C., Riccabona G., Rigo P., Schober O., Schumichen C., Schwarzrock R., Seybold K., Vogt H., Wolf F., Zechmann W.
ISSN
0029-5566 (Print)
Statut éditorial
Publié
Date de publication
08/1990
Volume
29
Numéro
4
Pages
135-43
Notes
Clinical Trial Comparative Study English Abstract Journal Article Multicenter Study --- Old month value: Aug
Résumé
A total of 226 patients was studied in a phase-III multicenter trial to compare the results of stress/rest 99mTc-MIBI with 201TI scintigraphy and/or coronary arteriography. The evaluation of planar and SPECT imaging was based on a semiquantitative visual scoring. A congruent diagnosis was generated from all planar 201TI and 99mTc-MIBI scintigrams performed in 36 patients. In 62 of 63 patients, SPECT-studies with 99mTc-MIBI and 201TI led to an identical diagnosis. In one patient a positive result was obtained with 201TI-SPECT whereas 99mTc-MIBI was negative. Segmental agreement for 1509 SPECT segments was 85.7%, for 554 planar segments it was 86.6%. In comparison to coronary arteriography, performed in 180 patients, the overall sensitivity for the correct diagnosis of coronary artery disease (CAD) was 86% for planar MIBI scintigraphy or 92% for MIBI-SPECT. Overall specificity was 100% for planar imaging and 57% for SPECT. The low specificity of MIBI-SPECT was probably due to high prevalence of CAD in this study population. In a subgroup of 43 patients, who underwent coronary angiography, identical results were found with 99mTc-MIBI and 201TI. Only one patient showed a positive scintigraphic result with both 99mTc-MIBI and 201TI without angiographically proven stenosis greater than 50% or prior myocardial infarction. Vessel sensitivities in stenosed coronary arteries (greater than 50% stenosis) were 54% for the LAD and 87% for the RCX/RCA areas with MIBI-SPECT, or 51% or 79% for planar scintigraphy, respectively. Vessel specificities for SPECT were 65% in the LAD or 52% in the RCX/RCA, or 90% or 83% in planar imaging.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Adult Aged Coronary Angiography Coronary Disease/radiography/*radionuclide imaging Female Humans Male Middle Aged Nitriles/*diagnostic use Organotechnetium Compounds/*diagnostic use Technetium Tc 99m Sestamibi Thallium Radioisotopes/diagnostic use Tomography, Emission-Computed, Single-Photon
Pubmed
Web of science
Création de la notice
25/01/2008 12:22
Dernière modification de la notice
03/03/2018 21:27
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