Hippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.

Détails

Ressource 1Demande d'une copie Sous embargo indéterminé.
Etat: Serval
Version: de l'auteur
ID Serval
serval:BIB_CBE44BB9009D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Hippocampal and amygdalar volume changes in elderly patients with Alzheimer's disease and schizophrenia.
Périodique
Psychiatry Research
Auteur(s)
Prestia A., Boccardi M., Galluzzi S., Cavedo E., Adorni A., Soricelli A., Bonetti M., Geroldi C., Giannakopoulos P., Thompson P., Frisoni G.
ISSN
0165-1781 (Print)
ISSN-L
0165-1781
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
192
Numéro
2
Pages
77-83
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Patients with Alzheimer's disease (AD) and schizophrenia display cognitive, behavioural disturbances and morphological abnormalities. Although these latter reflect progressive neurodegeneration in AD, their significance in schizophrenia is still unclear. We explored the patterns of hippocampal and amygdalar atrophy in those patients and their associations with clinical parameters. Structural magnetic resonance imaging was performed in 20 elderly schizophrenia patients, 20 AD and 19 healthy older controls. Hippocampal and amygdalar volumes were obtained by manual segmentation with a standardized protocol and compared among groups. In both schizophrenia and AD patients, left hippocampal and amygdalar volumes were significantly smaller. The hippocampus/amygdala ratio was significantly lower in schizophrenia compared to both AD cases [2.4 bilaterally, 95% C.I. 2.2 to 2.7] and healthy controls bilaterally [2.5, 95% C.I. 2.3 to 2.9 in left and 2.7, 95% C.I. 2.4 to 3.1 in right hemisphere]. In schizophrenia patients, a significant positive correlation was found between age at disease onset and the right hippocampus/amygdala volume ratio (Spearman rho=0.56). Negative symptoms correlated with higher right/left amygdala volume ratio (Spearman's rho=0.43). Our data show that unlike AD, the hippocampus/amygdala ratio is abnormally low and correlates with the age at onset in schizophrenia, being a neurodevelopmental signature of the disease.
Pubmed
Web of science
Création de la notice
16/05/2011 13:36
Dernière modification de la notice
03/03/2018 21:27
Données d'usage