Un guide pratique au traitement des gliomes [A practical guide for the management of gliomas]

Détails

ID Serval
serval:BIB_CB9BE167BD46
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Un guide pratique au traitement des gliomes [A practical guide for the management of gliomas]
Périodique
Bulletin du cancer
Auteur(s)
Stupp R., Pica A., Mirimanoff R.O., Michielin O.
ISSN
1769-6917[electronic]
Statut éditorial
Publié
Date de publication
2007
Volume
94
Numéro
9
Pages
817-22
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review - Publication Status: ppublish
Résumé
The management of gliomas in daily clinical practice is challenging. It requires a multidisciplinary and coordinated approach involving neurosurgery, radiotherapy and, finally, chemotherapy. Important progress has been made during the last years with the introduction of a combined treatment associating standard radiotherapy with concomitant chemotherapy using temozolomide, a novel alkylating agent. For the first time in many years a new treatment strategy translated into a significant prolongation of survival. In parallel, molecular markers (e.g. loss of heterozygosity on chromosomes 1p and 19q or methylation of the methyl-guanine methyl transferase [MGMT] gene promoter) allowed for identification of distinct subtypes of glioma or prediction of treatment response. In this "Practical Guide", we describe the daily practice and aim at answering some common questions in the management of patients suffering from glioblastoma, astrocytoma, oligodendroglioma and low grade glioma. The therapeutic options presented here are based on evidences from the literature. In the absence of documented evidence, the empirical choices from our local practice are explained and justified.
Mots-clé
Central Nervous System Neoplasms, Clinical Trials as Topic, Combined Modality Therapy, Disease Management, Glioma, Humans, Treatment Outcome
Pubmed
Web of science
Création de la notice
28/01/2008 12:22
Dernière modification de la notice
03/03/2018 21:26
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