Effects of beta-blockade on energy metabolism following burns.

Détails

ID Serval
serval:BIB_CB932BCDBB3F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Effects of beta-blockade on energy metabolism following burns.
Périodique
Burns
Auteur(s)
Breitenstein E., Chioléro R.L., Jéquier E., Dayer P., Krupp S., Schutz Y.
ISSN
0305-4179 (Print)
ISSN-L
0305-4179
Statut éditorial
Publié
Date de publication
1990
Volume
16
Numéro
4
Pages
259-264
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The purpose of this study was to compare the effects of propranolol administered either by i.v. infusion or by prolonged oral administration (4 days) during the first 3 weeks following burns. The resting metabolic rate (RMR) of 10 non-infected fasting burned patients (TBSA: 28 per cent, range 18-37 per cent) was determined four times consecutively by indirect calorimetry (open circuit hood system) following: (1) i.v. physiological saline; (2) i.v. propranolol infusion (2 micrograms/kg/min following a bolus of 80 micrograms/kg); (3) oral propranolol (40 mg q.i.d. during 4 +/- 1 days); and (4) in control patients. All patients showed large increases in both RMR (144 +/- 2 per cent of reference values) and in urinary catecholamine excretion (three to four times as compared to control values). The infusion of propranolol induced a significant decrease in RMR to 135 +/- 2 per cent and oral propranolol to 129 +/- 3 per cent of reference values. A decrease in lipid oxidation but no change in carbohydrate and protein oxidation were observed during propranolol administration. It is concluded that the decrease in RMR induced by propranolol was not influenced by the route of administration. The magnitude of the decrease in energy expenditure suggests that beta-adrenergic hyperactivity represents only one of the mediators of the hypermetabolic response to burn injury.
Mots-clé
Administration, Oral, Adult, Body Weight/drug effects, Burns/metabolism, Catecholamines/urine, Energy Metabolism/drug effects, Female, Heart Rate/drug effects, Humans, Injections, Intravenous, Lipid Metabolism, Male, Middle Aged, Propranolol/administration & dosage, Propranolol/blood
Pubmed
Web of science
Création de la notice
21/01/2008 14:08
Dernière modification de la notice
03/03/2018 21:26
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