Embryonic Purkinje Cells Grafted on the Surface of the Cerebellar Cortex Integrate in the Adult Unlesioned Cerebellum

Détails

ID Serval
serval:BIB_CB8ABB8B637E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Embryonic Purkinje Cells Grafted on the Surface of the Cerebellar Cortex Integrate in the Adult Unlesioned Cerebellum
Périodique
European Journal of Neuroscience
Auteur(s)
Rossi  F., Borsello  T., Strata  P.
ISSN
0953-816X (Print)
Statut éditorial
Publié
Date de publication
1992
Volume
4
Numéro
6
Pages
589-593
Notes
Journal article
Résumé
The presence of an injury or the selective degeneration of specific neuronal populations is commonly assumed to be a necessary prerequisite for the survival and the integration of grafted neurons in the recipient brain. In the present study we have placed solid grafts of cerebellar anlage in the fourth ventricle of adult rats, in close contact with the host cerebellar cortex, to assess the capacity of embryonic Purkinje cells to interact with adult neurons and integrate in the unlesioned cerebellar cortex. Numerous grafted Purkinje cells are indeed able to leave the implant and migrate into the host molecular layer, where they develop adult structural features. In addition, such cells are able to elicit the growth of host climbing fibre sprouts which end in newly formed arborizations impinging upon their dendritic trees. Climbing fibre collateral branches also penetrate the implant to innervate Purkinje cells which have not migrated in the host cerebellum. These results show that embryonic Purkinje cells are able to survive and integrate in an adult unlesioned cerebellar cortex. In addition, adult olivary axons respond to the increased size of the target population by expanding their terminal domain to innervate grafted Purkinje cells.
Pubmed
Création de la notice
24/01/2008 15:19
Dernière modification de la notice
03/03/2018 21:26
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