Skewed maturation of memory HIV-specific CD8 T lymphocytes

Détails

ID Serval
serval:BIB_CB67746EE255
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Skewed maturation of memory HIV-specific CD8 T lymphocytes
Périodique
Nature
Auteur(s)
Champagne  P., Ogg  G. S., King  A. S., Knabenhans  C., Ellefsen  K., Nobile  M., Appay  V., Rizzardi  G. P., Fleury  S., Lipp  M., Forster  R., Rowland-Jones  S., Sekaly  R. P., McMichael  A. J., Pantaleo  G.
ISSN
0028-0836 (Print)
Statut éditorial
Publié
Date de publication
03/2001
Volume
410
Numéro
6824
Pages
106-11
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Mar 1
Résumé
Understanding the lineage differentiation of memory T cells is a central question in immunology. We investigated this issue by analysing the expression of the chemokine receptor CCR7, which defines distinct subsets of naive and memory T lymphocytes with different homing and effector capacities and antiviral immune responses to HIV and cytomegalovirus. Ex vivo analysis of the expression of CD45RA and CCR7 antigens, together with in vitro analysis of the cell-division capacity of different memory CD8+ T-cell populations, identified four subsets of HIV- and CMV-specific CD8+ T lymphocytes, and indicated the following lineage differentiation pattern: CD45RA+ CCR7+ --> CD45RA- CCR7+ --> CD45RA- CCR7- --> CD45RA+ CCR7-. Here we demonstrate through analysis of cell division (predominantly restricted to the CCR7+ CD8+ T-cell subsets) that the differentiation of antigen-specific CD8+ T cells is a two-step process characterized initially by a phase of proliferation largely restricted to the CCR7+ CD8+ cell subsets, followed by a phase of functional maturation encompassing the CCR7- CD8+ cell subsets. The distribution of these populations in HIV- and CMV-specific CD8+ T cells showed that the HIV-specific cell pool was predominantly (70%) composed of pre-terminally differentiated CD45RA- CCR7- cells, whereas the CMV-specific cell pool consisted mainly (50%) of the terminally differentiated CD45RA+ CCR7- cells. These results demonstrate a skewed maturation of HIV-specific memory CD8+ T cells during HIV infection.
Mots-clé
Adult Antigens, CD45/biosynthesis CD8-Positive T-Lymphocytes/*immunology Cell Division Cell Lineage Cytomegalovirus/immunology Epitopes, T-Lymphocyte/immunology HIV/*immunology HIV Infections/*immunology Humans *Immunologic Memory Immunophenotyping Interferon Type II/biosynthesis Leukopoiesis Membrane Glycoproteins/biosynthesis Pore Forming Cytotoxic Proteins Receptors, Chemokine/biosynthesis T-Lymphocyte Subsets/immunology
Pubmed
Web of science
Création de la notice
25/01/2008 16:13
Dernière modification de la notice
20/08/2019 16:46
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