Antidepressants for the treatment of chronic pain.

Détails

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Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_CB3ECEE27130
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antidepressants for the treatment of chronic pain.
Périodique
Drugs
Auteur(s)
Verdu B., Decosterd I., Buclin T., Stiefel F., Berney A.
ISSN
0012-6667
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
68
Numéro
18
Pages
2611-2632
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review SAPHIRID:76035
Résumé
Chronic pain represents one of the most important public health problems and, in addition to classical analgesics, antidepressants are an essential part of the therapeutic strategy. This article reviews available evidence on the efficacy and safety of antidepressants in major chronic pain conditions; namely, neuropathic pain, headaches, low back pain, fibromyalgia, irritable bowel syndrome (IBS) and cancer pain. Studies, reviews and meta-analyses published from 1991 to March 2008 were retrieved through MEDLINE, PsycINFO and the Cochrane database using numerous key words for pain and antidepressants. In summary, evidence supports the use of tricyclic antidepressants in neuropathic pain, headaches, low back pain, fibromyalgia and IBS. The efficacy of the newer serotonin and norepinephrine reuptake inhibitors is less supported by evidence, but can be recommended in neuropathic pain, migraines and fibromyalgia. To date, evidence does not support an analgesic effect of serotonin reuptake inhibitors, but beneficial effects on well-being were reported in several chronic pain conditions. These results are discussed in the light of current insights in the neurobiology of pain, the reciprocal relationship between pain and depression, and future developments in this field of research.
Mots-clé
Animals, Antidepressive Agents, Chronic Disease, Databases as Topic, Humans, Models, Theoretical, Pain, Randomized Controlled Trials as Topic, Treatment Outcome
Pubmed
Web of science
Création de la notice
08/01/2009 8:56
Dernière modification de la notice
20/08/2019 15:46
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