Prevalence and malignancy risk of focal colorectal incidental uptake detected by (18)F-FDG-PET or PET/CT: a meta-analysis.

Détails

ID Serval
serval:BIB_CB1D04457AED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Prevalence and malignancy risk of focal colorectal incidental uptake detected by (18)F-FDG-PET or PET/CT: a meta-analysis.
Périodique
Radiology and oncology
Auteur(s)
Treglia G., Taralli S., Salsano M., Muoio B., Sadeghi R., Giovanella L.
ISSN
1318-2099 (Print)
ISSN-L
1318-2099
Statut éditorial
Publié
Date de publication
06/2014
Peer-reviewed
Oui
Volume
48
Numéro
2
Pages
99-104
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: epublish
Résumé
The aim of the study was to meta-analyze published data about prevalence and malignancy risk of focal colorectal incidentalomas (FCIs) detected by Fluorine-18-Fluorodeoxyglucose positron emission tomography or positron emission tomography/computed tomography ((18)F-FDG-PET or PET/CT).
A comprehensive computer literature search of studies published through July 31(st) 2012 regarding FCIs detected by (18)F-FDG-PET or PET/CT was performed. Pooled prevalence of patients with FCIs and risk of malignant or premalignant FCIs after colonoscopy or histopathology verification were calculated. Furthermore, separate calculations for geographic areas were performed. Finally, average standardized uptake values (SUV) in malignant, premalignant and benign FCIs were reported.
Thirty-two studies comprising 89,061 patients evaluated by (18)F-FDG-PET or PET/CT were included. The pooled prevalence of FCIs detected by (18)F-FDG-PET or PET/CT was 3.6% (95% confidence interval [95% CI]: 2.6-4.7%). Overall, 1,044 FCIs detected by (18)F-FDG-PET or PET/CT underwent colonoscopy or histopathology evaluation. Pooled risk of malignant or premalignant lesions was 68% (95% CI: 60-75%). Risk of malignant and premalignant FCIs in Asia-Oceania was lower compared to that of Europe and America. A significant overlap in average SUV was found between malignant, premalignant and benign FCIs.
FCIs are observed in a not negligible number of patients who undergo (18)F-FDG-PET or PET/CT studies with a high risk of malignant or premalignant lesions. SUV is not reliable as a tool to differentiate between malignant, premalignant and benign FCIs. Further investigation is warranted whenever FCIs are detected by (18)F-FDG-PET or PET/CT.

Mots-clé
PET/CT, colonic uptake, colorectal cancer, fluorodeoxyglucose, focal uptake, incidentaloma
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/08/2017 19:04
Dernière modification de la notice
09/05/2019 1:16
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