Acute endotoxemia protracts leukocyte / endothelium interaction after local ischemia and reperfusion in striated muscle.

Détails

ID Serval
serval:BIB_CB190B0BE7D3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Acute endotoxemia protracts leukocyte / endothelium interaction after local ischemia and reperfusion in striated muscle.
Périodique
European Journal of Medical Research
Auteur(s)
Galla T.J., Borges J., Kawasaki K., Lehr H., Messmer K.
ISSN
0949-2321 (Print)
ISSN-L
0949-2321
Statut éditorial
Publié
Date de publication
2000
Volume
5
Numéro
3
Pages
93-100
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
Postischemic reperfusion injury and endotoxemia have been shown to promote multiple organ failure in polytraumatized patients. Both pathomechanisms comprise endothelial injury, leukocyte activation, and enhanced leukocyte/endothelium interaction in the microcirculation. Using a dorsal skinfold chamber model for intravital microscopy in striated muscle of awake hamsters, we investigated whether acute endotoxemia enhances postischemic leukocyte/endothelium interaction. - In control animals (n = 8), reperfusion after 2 hours of pressure induced ischemia elicited the rolling and adhesion of fluorescently stained leukocytes to the endothelium of postcapillary venules with a maximum at 0.5 and 2 hours after reperfusion and a decline towards preischemic values after 24 hours. Postischemic leukocyte adhesion was enhanced and protracted in animals where acute endotoxemia was induced through intravenous injection of endotoxin (Salmonella abortus equi, 0.1 microg¿kg superset-1) either 10 minutes prior to ischemia (n = 8) or to reperfusion (n = 8). - These results suggest that acute endotoxemia has the potential to aggravate the leukocyte-triggered reperfusion damage to striated muscle and presumably to vital organs and thus favours the development of multiple organ failure after primarily successful reperfusion.
Mots-clé
Animals, Blood Flow Velocity, Cell Adhesion, Cricetinae, Endothelium, Vascular/physiology, Endothelium, Vascular/physiopathology, Endotoxemia/physiopathology, Endotoxins, Hemodynamics, Ischemia/physiopathology, Leukocyte Count, Leukocytes/physiology, Lipopolysaccharides, Mesocricetus, Muscle, Skeletal/blood supply, Muscle, Skeletal/physiology, Reference Values, Reperfusion, Salmonella, Venules/physiology, Venules/physiopathology
Pubmed
Création de la notice
25/11/2011 20:52
Dernière modification de la notice
03/03/2018 21:26
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