Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression.

Détails

Ressource 1Télécharger: 27002284.pdf (488.72 [Ko])
Etat: Public
Version: Author's accepted manuscript
Document(s) secondaire(s)
Télécharger: 27002284_supplementary tables.pdf (382.91 [Ko])
Etat: Public
Version: Supplementary document
ID Serval
serval:BIB_CB055B9E66F0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression.
Périodique
Journal of affective disorders
Auteur(s)
Quteineh L., Preisig M., Rivera M., Milaneschi Y., Castelao E., Gholam-Rezaee M., Vandenberghe F., Saigi-Morgui N., Delacrétaz A., Cardinaux J.R., Willemsen G., Boomsma D.I., Penninx B.W., Ching-López A., Conus P., Eap C.B.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Statut éditorial
Publié
Date de publication
01/07/2016
Peer-reviewed
Oui
Volume
198
Pages
43-49
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Psychiatric disorders have been hypothesized to share common etiological pathways with obesity, suggesting related neurobiological bases. We aimed to examine whether CRTC1 polymorphisms were associated with major depressive disorder (MDD) and to test the association of these polymorphisms with obesity markers in several large case-control samples with MDD.
The association between CRTC1 polymorphisms and MDD was investigated in three case-control samples with MDD (PsyCoLaus n1=3,362, Radiant n2=3,148 and NESDA/NTR n3=4,663). The effect of CRTC1 polymorphisms on obesity markers was then explored.
CRTC1 polymorphisms were not associated with MDD in the three samples. CRTC1 rs6510997C>T was significantly associated with fat mass in the PsyCoLaus study. In fact, a protective effect of this polymorphism was found in MDD cases (n=1,434, β=-1.32%, 95% CI -2.07 to -0.57, p<0.001), but not in controls. In the Radiant study, CRTC1 polymorphisms were associated with BMI, exclusively in individuals with MDD (n=2,138, β=-0.75kg/m(2), 95% CI -1.30 to -0.21, p=0.007), while no association with BMI was found in the NESDA/NTR study.
Estimated fat mass using bioimpedance that capture more accurately adiposity was only present in the PsyCoLaus sample.
CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals. Therefore, the weak association previously reported in the population-based samples was driven by cases diagnosed with lifetime MDD. However, CRTC1 seems not to be implicated directly in the development of psychiatric diseases.

Mots-clé
Adipose Tissue, Adult, Biomarkers, Body Mass Index, Case-Control Studies, Depressive Disorder, Major/complications, Depressive Disorder, Major/genetics, Female, Humans, Male, Middle Aged, Obesity/complications, Obesity/genetics, Obesity/physiopathology, Polymorphism, Single Nucleotide/genetics, Transcription Factors/genetics, Genetic polymorphisms, Major depressive disorder, Obesity, Pharmacogenetics, Psychiatric disorders, Psychotropic drugs
Pubmed
Web of science
Création de la notice
29/03/2016 12:59
Dernière modification de la notice
20/08/2019 16:45
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