Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression.

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Version: Author's accepted manuscript
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Version: Supplementary document
Serval ID
serval:BIB_CB055B9E66F0
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Association of CRTC1 polymorphisms with obesity markers in subjects from the general population with lifetime depression.
Journal
Journal of affective disorders
Author(s)
Quteineh L., Preisig M., Rivera M., Milaneschi Y., Castelao E., Gholam-Rezaee M., Vandenberghe F., Saigi-Morgui N., Delacrétaz A., Cardinaux J.R., Willemsen G., Boomsma D.I., Penninx B.W., Ching-López A., Conus P., Eap C.B.
ISSN
1573-2517 (Electronic)
ISSN-L
0165-0327
Publication state
Published
Issued date
01/07/2016
Peer-reviewed
Oui
Volume
198
Pages
43-49
Language
english
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Abstract
Psychiatric disorders have been hypothesized to share common etiological pathways with obesity, suggesting related neurobiological bases. We aimed to examine whether CRTC1 polymorphisms were associated with major depressive disorder (MDD) and to test the association of these polymorphisms with obesity markers in several large case-control samples with MDD.
The association between CRTC1 polymorphisms and MDD was investigated in three case-control samples with MDD (PsyCoLaus n1=3,362, Radiant n2=3,148 and NESDA/NTR n3=4,663). The effect of CRTC1 polymorphisms on obesity markers was then explored.
CRTC1 polymorphisms were not associated with MDD in the three samples. CRTC1 rs6510997C>T was significantly associated with fat mass in the PsyCoLaus study. In fact, a protective effect of this polymorphism was found in MDD cases (n=1,434, β=-1.32%, 95% CI -2.07 to -0.57, p<0.001), but not in controls. In the Radiant study, CRTC1 polymorphisms were associated with BMI, exclusively in individuals with MDD (n=2,138, β=-0.75kg/m(2), 95% CI -1.30 to -0.21, p=0.007), while no association with BMI was found in the NESDA/NTR study.
Estimated fat mass using bioimpedance that capture more accurately adiposity was only present in the PsyCoLaus sample.
CRTC1 polymorphisms seem to play a role with obesity markers in individuals with MDD rather than non-depressive individuals. Therefore, the weak association previously reported in the population-based samples was driven by cases diagnosed with lifetime MDD. However, CRTC1 seems not to be implicated directly in the development of psychiatric diseases.

Keywords
Adipose Tissue, Adult, Biomarkers, Body Mass Index, Case-Control Studies, Depressive Disorder, Major/complications, Depressive Disorder, Major/genetics, Female, Humans, Male, Middle Aged, Obesity/complications, Obesity/genetics, Obesity/physiopathology, Polymorphism, Single Nucleotide/genetics, Transcription Factors/genetics, Genetic polymorphisms, Major depressive disorder, Obesity, Pharmacogenetics, Psychiatric disorders, Psychotropic drugs
Pubmed
Web of science
Create date
29/03/2016 11:59
Last modification date
20/08/2019 15:45
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