Fatal flecainide intoxication.

Détails

ID Serval
serval:BIB_CAD9862B946B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Titre
Fatal flecainide intoxication.
Périodique
Forensic Science International
Auteur(s)
Romain N., Giroud C., Michaud K., Augsburger M., Mangin P.
ISSN
0379-0738
Statut éditorial
Publié
Date de publication
1999
Peer-reviewed
Oui
Volume
106
Numéro
2
Pages
115-123
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Résumé
A fatal case attributed to flecainide acetate (Tambocor), a class Ic antiarrythmic drug, is presented. Flecainide was detected by GC/MS in gastric contents, blood and liver as well. The urine analysis revealed the presence of its dealkylated metabolite. Body fluids and tissue concentrations determined by GC/ECD were 7.7 mg/kg in femoral blood, 0.26 mg/kg in bile, 18 mg/kg in liver, 0.17 mg/kg in cerebrospinal fluid, 0.22 mg/kg in brain cortex and 28.9 mg/kg in urine. The total amount of flecainide in gastric contents was about 43 mg. Even taking into account the postmortem redistribution of flecainide, its blood level still remains in the toxic range.
Mots-clé
Aged, Anti-Arrhythmia Agents, Bile, Body Fluids, Cerebral Cortex, Fatal Outcome, Flecainide, Gas Chromatography-Mass Spectrometry, Gastrointestinal Contents, Humans, Liver, Male, Overdose, Suicide, Tissue Distribution
Pubmed
Web of science
Création de la notice
08/02/2008 18:44
Dernière modification de la notice
20/08/2019 16:45
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