Rôle de la bradykinine dans l'hypotension induite par le fragment actif dérivé du facteur XII [Role of bradykinin in hypotension induced by the active factor derived from factor XII]

Details

Serval ID
serval:BIB_CAB52D0DB4A4
Type
Article: article from journal or magazin.
Collection
Publications
Institution
Title
Rôle de la bradykinine dans l'hypotension induite par le fragment actif dérivé du facteur XII [Role of bradykinin in hypotension induced by the active factor derived from factor XII]
Journal
Schweizerische medizinische Wochenschrift
Author(s)
Waeber B., Nussberger J., Brunner H.R., de Agostini A., Schapira M.
ISSN
0036-7672
Publication state
Published
Issued date
1984
Peer-reviewed
Oui
Volume
114
Number
48
Pages
1749-51
Language
french
Notes
Publication types: English Abstract ; Journal Article - Publication Status: ppublish
Abstract
The active fragment derived from factor XII (factor XIIf) was purified from human plasma and administered intravenously to normotensive conscious rats. Factor XIIf-mediated hypotension was dose-dependent and augmented by pretreatment with captopril, an inhibitor of the angiotensin I- and bradykinin-processing enzyme. In contrast, factor XIIf-induced hypotension was not enhanced by blockade of the renin-angiotensin system by saralasin, a competitive antagonist of angiotensin II at the vascular receptor level. These results suggest that factor XIIf-mediated hypotension is due to the formation of bradykinin.
Keywords
Angiotensin-Converting Enzyme Inhibitors, Animals, Bradykinin, Captopril, Factor XII, Factor XIIa, Hypotension, Male, Peptide Fragments, Rats, Rats, Inbred Strains, Saralasin
Pubmed
Web of science
Create date
25/01/2008 15:28
Last modification date
20/08/2019 15:45
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